[HTML][HTML] The thioredoxin system of mammalian cells and its modulators
AA Hasan, E Kalinina, V Tatarskiy, A Shtil - Biomedicines, 2022 - mdpi.com
Oxidative stress involves the increased production and accumulation of free radicals,
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
J Nordberg, ESJ Arnér - Free radical biology and medicine, 2001 - Elsevier
Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
Thioredoxin and redox signaling: Roles of the thioredoxin system in control of cell fate
A Matsuzawa - Archives of biochemistry and biophysics, 2017 - Elsevier
Reactive oxygen species (ROS) are not only cytotoxic products from external and internal
environment, but also important mediators of redox signaling. Therefore, thioredoxin (Trx) as …
environment, but also important mediators of redox signaling. Therefore, thioredoxin (Trx) as …
Effects of mammalian thioredoxin reductase inhibitors
ESJ Arnér - Reactive Oxygen Species: Network Pharmacology and …, 2021 - Springer
The mammalian thioredoxin system is driven by NADPH through the activities of isoforms of
the selenoprotein thioredoxin reductase (TXNRD, TrxR), which in turn help to keep …
the selenoprotein thioredoxin reductase (TXNRD, TrxR), which in turn help to keep …
[HTML][HTML] The role of the thioredoxin detoxification system in cancer progression and resistance
M Jovanović, A Podolski-Renić, M Krasavin… - Frontiers in Molecular …, 2022 - frontiersin.org
The intracellular redox homeostasis is a dynamic balancing system between the levels of
free radical species and antioxidant enzymes and small molecules at the core of cellular …
free radical species and antioxidant enzymes and small molecules at the core of cellular …
Thioredoxin signaling pathways in cancer
Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …
maintain redox stability in cells and is involved in regulating multiple redox-dependent …
Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance
The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …
Thioredoxin: friend or foe in human disease?
A Burke-Gaffney, MEJ Callister, H Nakamura - Trends in pharmacological …, 2005 - cell.com
Thioredoxin (Trx), a small, ubiquitous thiol [sulfydryl (-SH)] protein, is one of the most
important regulators of reduction–oxidation (redox) balance and, thus, redox-controlled cell …
important regulators of reduction–oxidation (redox) balance and, thus, redox-controlled cell …
The thioredoxin antioxidant system
J Lu, A Holmgren - Free radical biology and medicine, 2014 - Elsevier
The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
Redox regulation of human thioredoxin network
N Kondo, H Nakamura, H Masutani… - Antioxidants & redox …, 2006 - liebertpub.com
Oxidative stresses are largely mediated by intracellular protein oxidations by reactive
oxygen species (ROS). Host cells are equipped with antioxidants that scavenge ROS. The …
oxygen species (ROS). Host cells are equipped with antioxidants that scavenge ROS. The …