Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet

JE Mells, PP Fu, S Sharma, D Olson… - American Journal …, 2012 - journals.physiology.org
The aims of this study were designed to determine whether liraglutide, a long-acting
glucagon-like peptide, could reverse the adverse effects of a diet high in fat that also …

Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats

BP Cummings, KL Stanhope, JL Graham, DG Baskin… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE The efficacy of liraglutide, a human glucagon-like peptide-1 (GLP-1) analog, to
prevent or delay diabetes in UCD-T2DM rats, a model of polygenic obese type 2 diabetes …

The glucagon-like peptide-1 analogue liraglutide inhibits oxidative stress and inflammatory response in the liver of rats with diet-induced non-alcoholic fatty liver …

H Gao, Z Zeng, H Zhang, X Zhou, L Guan… - Biological and …, 2015 - jstage.jst.go.jp
Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, has been demonstrated to reduce
hepatic steatosis. However, the mechanism of the lipid-lowering effect of liraglutide in the …

Liraglutide improves insulin sensitivity in high fat diet induced diabetic mice through multiple pathways

JY Zhou, A Poudel, R Welchko, N Mekala… - European journal of …, 2019 - Elsevier
Abstract Glucagon like peptide-1 (GLP-1) promotes postprandial insulin secretion.
Liraglutide, a full agonist of the GLP-1 receptor, reduces body weight, improve insulin …

A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity

MH Noyan-Ashraf, EA Shikatani, I Schuiki… - Circulation, 2013 - Am Heart Assoc
Background—Cardiac consequences of obesity include inflammation, hypertrophy, and
compromised energy metabolism. Glucagon-like peptide-1 is an incretin hormone capable …

Liraglutide enhances insulin sensitivity by activating AMP-activated protein kinase in male Wistar rats

S Yamazaki, H Satoh, T Watanabe - Endocrinology, 2014 - academic.oup.com
We investigated the effects of liraglutide on insulin sensitivity and glucose metabolism in
male Wistar rats. The rats were fed a normal chow diet (NCD) or a 60% high-fat diet (HFD) …

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary‐induced obesity and insulin …

DW Porter, BD Kerr, PR Flatt… - Diabetes, Obesity and …, 2010 - Wiley Online Library
Aim: Liraglutide is a long‐acting glucagon‐like peptide‐1 (GLP‐1) mimetic which is a
treatment option for type 2 diabetes. GLP‐1 peptides, including Liraglutide, cross the blood …

Liraglutide improves non-alcoholic fatty liver disease in diabetic mice by modulating inflammatory signaling pathways

Y Luo, P Yang, Z Li, Y Luo, J Shen, R Li… - Drug Design …, 2019 - Taylor & Francis
Background Many chronic metabolic diseases, such as obesity and type 2 diabetes (T2DM),
are closely related to a chronic low-grade inflammatory state in tissues. The high prevalence …

Liraglutide, a once‐daily human glucagon‐like peptide‐1 analog, minimizes food intake in severely obese minipigs

K Raun, P Von Voss, LB Knudsen - Obesity, 2007 - Wiley Online Library
Objectives: To evaluate the efficacy of liraglutide, a new, stable, once‐daily human analog of
glucagon‐like peptide‐1, in a new animal model of obesity. Research Methods and …

Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor …

K Raun, P von Voss, CF Gotfredsen, V Golozoubova… - Diabetes, 2007 - Am Diabetes Assoc
Metabolic effects of the glucagon-like peptide-1 analog liraglutide and the dipeptidyl
peptidase-IV inhibitor vildagliptin were compared in rats made obese by supplementary …