Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and
metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We …

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a
transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells …

Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to
environmental stresses, its contributions in organ transplantation have not been …

Neutrophils, the largest innate immune cell population in humans, are the primary
proinflammatory sentinel in the ischemia-reperfusion injury (IRI) mechanism in orthotopic …

A dysbalance between effector T cells (Tconv) and regulatory T cells (Tregs) and impaired
Treg function can cause autoimmune liver disease. Therefore, it is important to identify …

Objectives Hepatocytic CEACAM1 plays a critical role in NASH pathogenesis, as bolstered
by the development of insulin resistance, visceral obesity, steatohepatitis and fibrosis in …

Liver metastasis is the predominant cause of colorectal cancer (CRC)-related mortality in
developed countries. Carcinoembryonic antigen-related cell adhesion molecule 1 …

Background The two isoforms of carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1), 1 with a long cytoplasmic domain (CEACAM1-L) and 1 with a short (CEACAM1 …

Despite the diverse etiologies of drug-induced liver injury (DILI), innate immunity activation
is a common feature involved in DILI progression. However, the involvement of innate …

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. Marie-
Luise Berres, Rory R. Koenen, Anna Rueland, Mirko Moreno Zaldivar, Daniel Heinrichs …