Efficient tissue‐specific expression of bovine α‐lactalbumin in transgenic mice
JL VILOTTE, S Soulier, MG STINNAKRE… - European journal of …, 1989 - Wiley Online Library
Transgenic mice carrying a 3.2‐kb genomic fragment comprising the bovine α‐lactalbumin
gene transcription unit with 750 bp and 336 bp of 5′ and 3′ flanking regions, respectively …
gene transcription unit with 750 bp and 336 bp of 5′ and 3′ flanking regions, respectively …
Expression analysis of ruminant α‐lactalbumin in transgenic mice: Developmental regulation and general location of important cis‐regulatory elements
S Soulier, JL Vilotte, MG Stinnakre, JC Mercier - FEBS letters, 1992 - Wiley Online Library
The bovine α‐lactalbumin transgene with 750 bp and 336 bp of the 5′ and 3′ flanking
region, respectively, is developmentally regulated as its endogenous counterpart in …
region, respectively, is developmentally regulated as its endogenous counterpart in …
Structure and expression of the guinea-pig α-lactalbumin gene
JE Laird, L Jack, L Hall, AP Boulton, D Parker… - Biochemical …, 1988 - portlandpress.com
The entire guinea-pig alpha-lactalbumin gene was isolated from a genomic DNA library
constructed in the bacteriophage lambda L47. The complete nucleotide sequence of the …
constructed in the bacteriophage lambda L47. The complete nucleotide sequence of the …
Elements within the β-lactoglobulin gene inhibit expression of human serum albumin cDNA and minigenes in transfected cells but rescue their expression in the …
I Barash, M Nathan, R Kari, N Ilan, M Shani… - Nucleic acids …, 1996 - academic.oup.com
Two new β-lactoglobulin (BLG)/human serum albumin (HSA) hybrid gene vectors were
constructed and tested for expression in COS-7 cells and in transgenic mice. The HSA …
constructed and tested for expression in COS-7 cells and in transgenic mice. The HSA …
Position-independent and copy-number-related expression of a goat bacterial artificial chromosome α-lactalbumin gene in transgenic mice
MG STINNAKRE, S SOULIER, L Schibler… - Biochemical …, 1999 - portlandpress.com
A bacterial artificial chromosome goat insert comprising the α-lactalbumin-encoding
transcription unit with approximately 150 and 10 kb of 5´-and 3´-flanking sequences …
transcription unit with approximately 150 and 10 kb of 5´-and 3´-flanking sequences …
Position‐independent and high‐level expression of human α‐lactalbumin in the milk of transgenic rats carrying a 210‐kb YAC DNA
Y Fujiwara, M Miwa, R Takahashi… - Molecular …, 1997 - Wiley Online Library
The level of expression of transgenes in transgenic animals varies among lines, and is often
much lower than that of endogenous genes (position effects). In order to surmount position …
much lower than that of endogenous genes (position effects). In order to surmount position …
Secretion of bovine α‐lactalbumin into the milk of transgenic rats
SI Hochi, T Ninomiya, M Waga‐Homma… - Molecular …, 1992 - Wiley Online Library
Bovine α‐lactalbumin (bβLA) gene prepared by polymerase chain reaction was introduced
into rat genomes by microinjection. Out of 17 transgenic rat lines, 11 secreted bαLA into their …
into rat genomes by microinjection. Out of 17 transgenic rat lines, 11 secreted bαLA into their …
Expression of human serum albumin in the milk of transgenic mice
M Shani, I Barash, M Nathan, G Ricca, GH Searfoss… - Transgenic …, 1992 - Springer
We have tested the feasibility of producing large quantities of human serum albumin (HSA)
in the milk of transgenic livestock by generating transgenic mice as a model system. The …
in the milk of transgenic livestock by generating transgenic mice as a model system. The …
Ectopic expression of β-lactoglobulin/human serum albumin fusion genes in transgenic mice: hormonal regulation andin situ localization
I Barash, A Faerman, T Ratovitsky, R Puzis… - Transgenic …, 1994 - Springer
We produced transgenic mice carrying the native sheep β-lactoglobulin (BLG) or fusion
genes composed of the BLG promoter and human serum albumin (HSA) minigenes. BLG …
genes composed of the BLG promoter and human serum albumin (HSA) minigenes. BLG …
Molecular cloning and nucleotide sequence of a bovine α-lactalbumin cDNA
WL Hurley, LA Schuler - Gene, 1987 - Elsevier
A cDNA clone for the bovine milk protein, α-lactalbumin (αLA), has been identified using a
rat cDNA probe. The bovine cDNA clone is 703 nucleotides (nt) long, contains 8 nt of 5' …
rat cDNA probe. The bovine cDNA clone is 703 nucleotides (nt) long, contains 8 nt of 5' …
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