Background The strong association between epidermal barrier gene variants and Atopic
Dermatitis (AD) highlights that impaired skin barrier is a key feature in the pathogenesis of …

BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive
immune response to allergens, 2 cardinal features that are caused in part by epidermal …

Tight junctions are important for skin barrier function. The tight junction protein claudin 1
(Cldn-1) has been reported to be down-regulated in nonlesional skin of atopic dermatitis …

Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. It was recently
noted that the characteristics of epidermal barrier functions critically influence the …

Atopic march refers to the phenomenon wherein the occurrence of asthma and food allergy
tends to increase after atopic dermatitis. The mechanism underlying the progression of …

Background Hereditary factors are involved in the pathogenesis of atopic dermatitis (AD).
However, AD‐related gene variations are significantly different across ethnicities. Aim To …

Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in
frequency in recent decades and now affects∼ 20% of the population in the developed …

Background The tight junction (TJ) barrier is located in the granular layer of the epidermis.
Filaggrin deficiency predisposes patients to atopic dermatitis (AD) by impairing stratum …

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability.
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …

Background Atopic dermatitis (AD) is an itchy, chronic and inflammatory skin condition, with
dysfunctional immune response and skin barrier defects. Reduction of filaggrin (FLG) and …