Bioactive compounds from sour orange inhibit colon cancer cell proliferation and induce cell cycle arrest

GK Jayaprakasha, Y Jadegoud… - Journal of agricultural …, 2010 - ACS Publications
Epidemiological studies suggest that dietary limonoids and phytosterols offer protection from
certain types of cancers. Potential cancer preventive constituents of sour orange (Citrus …

Novel triterpenoid from Citrus aurantium L. possesses chemopreventive properties against human colon cancer cells

GK Jayaprakasha, KK Mandadi, SM Poulose… - Bioorganic & medicinal …, 2008 - Elsevier
Potential cancer preventive constituents of sour orange (Citrus aurantium L.) were isolated
and identified from EtOAc extract of sour orange. Crude EtOAc extract was purified using …

Citrus monoterpenes: potential source of phytochemicals for cancer prevention

KN Chidambara Murthy, GK Jayaprakasha… - Emerging trends in …, 2012 - ACS Publications
Dietary monoterpenes are non-nutritive volatile principles found in citrus and other regularly
consumed plant constituents. Monoterpenes are gaining significant importance as major …

Cancer chemopreventive properties of citrus limonoids

J Kim, GK Jayaprakasha, A Vikram… - Emerging trends in …, 2012 - ACS Publications
Limonoids constitute one of the major phytochemicals along with flavonoids, coumarins, and
carotenoids in citrus. Limonoids were shown to possess cancer preventive properties. In the …

Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis

KN Chidambara Murthy, GK Jayaprakasha… - Journal of agricultural …, 2011 - ACS Publications
The current study was an attempt to elucidate the mechanism of human colon cancer cell
proliferation inhibition by limonin and limonin glucoside (LG) isolated from seeds of Citrus …

Antiproliferative activities of citrus flavonoids against six human cancer cell lines

JA Manthey, N Guthrie - Journal of Agricultural and Food …, 2002 - ACS Publications
Citrus fruits contain high concentrations of several classes of phenols, including numerous
hydroxycinnamates, flavonoid glycosides, and polymethoxylated flavones. The latter group …

Differential inhibition of human colon cancer cells by structurally similar flavonoids of citrus

KNC Murthy, J Kim, A Vikram, BS Patil - Food Chemistry, 2012 - Elsevier
A number of studies in the recent years have evaluated the anti-proliferative activity of
flavonoids. Although certain studies investigated the structure–activity based on the …

Differential inhibition of human cancer cell proliferation by citrus limonoids

Q Tian, EG Miller, H Ahmad, L Tang, BS Patil - Nutrition and cancer, 2001 - Taylor & Francis
Limonoids have been shown to inhibit the growth of estrogen receptor-negative and-positive
human breast cancer cells in culture. The primary objective of this study was to test the …

Antiproliferative effects of citrus limonoids against human neuroblastoma and colonic adenocarcinoma cells

SM Poulose, ED Harris, BS Patil - Nutrition and cancer, 2006 - Taylor & Francis
Limonoids, a family of triterpenoids with putative anticancer properties, occur in fruits as
glucosides and aglycones. Both highly purified forms were isolated from seeds and …

5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis

JR Patil, GK Jayaprakasha, J Kim, KNC Murthy… - Planta …, 2013 - thieme-connect.com
For the first time, three coumarins were isolated from the hexane extract of limes (Citrus
aurantifolia) and purified by flash chromatography. The structures were identified by NMR …