Type 2 Diabetes results from a complex physiologic process that includes the pancreatic
beta cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and …

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies
have examined T2DM using genome-wide association approaches in this ethnicity. The aim …

Abstract Purpose of Review To provide an updated summary of discoveries made to date
resulting from genome-wide association study (GWAS) and sequencing studies, and to …

OBJECTIVE Genome-wide association studies have begun to elucidate the genetic
architecture of type 2 diabetes. We examined whether single nucleotide polymorphisms …

Recent large genome-wide association studies (GWAS) have identified multiple loci which
harbor genetic variants associated with type 2 diabetes mellitus (T2D), many of which …

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease
(CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both …

Most signals detected by genome-wide association studies map to non-coding sequence
and their tissue-specific effects influence transcriptional regulation. However, key tissues …

Compared to the successful probing of genetic causes of monogenic disorders, dissecting
the genetics of complex polygenic diseases has until recently been a fairly slow and …

Background The prevalence and incidence of type 2 diabetes (T2D), representing> 90% of
all cases of diabetes, are increasing rapidly worldwide. Identification of individuals at high …

During the past 7 years, genome-wide association studies have shed light on the
contribution of common genomic variants to the genetic architecture of type 2 diabetes …