Drugs targeting mitochondrial functions to control tumor cell growth

N Dias, C Bailly - Biochemical pharmacology, 2005 - Elsevier
Mitochondria, the power houses of the cell, are at the cross-road of many cellular pathways.
They play a central role in energy metabolism, regulate calcium flux and are implicated in …

Mitochondrial role in life and death of the cell

HC Lee, YH Wei - Journal of biomedical science, 2000 - karger.com
Mitochondria are the major ATP producer of the mammalian cell. Moreover, mitochondria
are also the main intracellular source and target of reactive oxygen species (ROS) that are …

Mitochondrial transfer in cancer: a comprehensive review

LX Zampieri, C Silva-Almeida, JD Rondeau… - International journal of …, 2021 - mdpi.com
Depending on their tissue of origin, genetic and epigenetic marks and microenvironmental
influences, cancer cells cover a broad range of metabolic activities that fluctuate over time …

The mitochondrion as an emerging therapeutic target in cancer

KG Roth, I Mambetsariev, P Kulkarni… - Trends in molecular …, 2020 - cell.com
Mitochondria have emerged as important pharmacological targets because of their key role
in cellular proliferation and death. In tumor tissues, mitochondria can switch metabolic …

Somatic mitochondrial DNA mutations in human cancers

M Yu - Advances in clinical chemistry, 2012 - books.google.com
Mitochondria are ubiquitous organelles in eukaryotic cells principally responsible for
regulating cellular energy metabolism, free radical production, and the execution of …

Mitochondria: a hub of redox activities and cellular distress control

P Kakkar, BK Singh - Molecular and cellular biochemistry, 2007 - Springer
In their reductionist approach in unraveling phenomena inside the cell, scientists in recent
times have focused attention to mitochondria. An organelle with peculiar evolutionary history …