Drugs targeting mitochondrial functions to control tumor cell growth
N Dias, C Bailly - Biochemical pharmacology, 2005 - Elsevier
Mitochondria, the power houses of the cell, are at the cross-road of many cellular pathways.
They play a central role in energy metabolism, regulate calcium flux and are implicated in …
They play a central role in energy metabolism, regulate calcium flux and are implicated in …
Mitochondrial role in life and death of the cell
HC Lee, YH Wei - Journal of biomedical science, 2000 - karger.com
Mitochondria are the major ATP producer of the mammalian cell. Moreover, mitochondria
are also the main intracellular source and target of reactive oxygen species (ROS) that are …
are also the main intracellular source and target of reactive oxygen species (ROS) that are …
Mitochondrial transfer in cancer: a comprehensive review
LX Zampieri, C Silva-Almeida, JD Rondeau… - International journal of …, 2021 - mdpi.com
Depending on their tissue of origin, genetic and epigenetic marks and microenvironmental
influences, cancer cells cover a broad range of metabolic activities that fluctuate over time …
influences, cancer cells cover a broad range of metabolic activities that fluctuate over time …
The mitochondrion as an emerging therapeutic target in cancer
KG Roth, I Mambetsariev, P Kulkarni… - Trends in molecular …, 2020 - cell.com
Mitochondria have emerged as important pharmacological targets because of their key role
in cellular proliferation and death. In tumor tissues, mitochondria can switch metabolic …
in cellular proliferation and death. In tumor tissues, mitochondria can switch metabolic …
Somatic mitochondrial DNA mutations in human cancers
M Yu - Advances in clinical chemistry, 2012 - books.google.com
Mitochondria are ubiquitous organelles in eukaryotic cells principally responsible for
regulating cellular energy metabolism, free radical production, and the execution of …
regulating cellular energy metabolism, free radical production, and the execution of …
Mitochondria: a hub of redox activities and cellular distress control
In their reductionist approach in unraveling phenomena inside the cell, scientists in recent
times have focused attention to mitochondria. An organelle with peculiar evolutionary history …
times have focused attention to mitochondria. An organelle with peculiar evolutionary history …