RETRACTED ARTICLE: Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures

VN Ivanov, PW Grabham, CC Wu, TK Hei - Scientific reports, 2020 - nature.com
Radiotherapy combined with chemotherapy is the major treatment modality for human
glioblastoma multiforme (GBM). GBMs eventually relapse after treatment and the average …

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

T Huang, T Xu, Y Wang, Y Zhou, D Yu, Z Wang, L He… - Autophagy, 2021 - Taylor & Francis
Glioma is the most common primary malignant brain tumor with poor survival and limited
therapeutic options. The non-psychoactive phytocannabinoid cannabidiol (CBD) has been …

[HTML][HTML] Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells

VN Ivanov, J Wu, TJC Wang, TK Hei - Oncotarget, 2019 - ncbi.nlm.nih.gov
Despite advances in glioblastoma (GBM) therapy, prognosis of the disease remains poor
with a low survival rate. Cannabidiol (CBD) can induce cell death and enhance …

[HTML][HTML] Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways

VN Ivanov, J Wu, TK Hei - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The
challenging problem in cancer treatment is to find a way to upregulate radiosensitivity of …

Cannabidiol stimulates A ml‐1a‐dependent glial differentiation and inhibits glioma stem‐like cells proliferation by inducing autophagy in a TRPV 2‐dependent …

M Nabissi, MB Morelli, C Amantini… - … journal of cancer, 2015 - Wiley Online Library
Glioma stem‐like cells (GSCs) correspond to a tumor cell subpopulation, involved in
glioblastoma multiforme (GBM) tumor initiation and acquired chemoresistance. Currently …

Inhalant cannabidiol inhibits glioblastoma progression through regulation of tumor microenvironment

H Khodadadi, ÉL Salles, A Alptekin… - Cannabis and …, 2023 - liebertpub.com
Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of
diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) …

The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

KA Scott, AG Dalgleish, WM Liu - Molecular cancer therapeutics, 2014 - AACR
High-grade glioma is one of the most aggressive cancers in adult humans and long-term
survival rates are very low as standard treatments for glioma remain largely unsuccessful …

Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon …

X Sun, L Zhou, Y Wang, G Deng, X Cao, B Ke… - Journal of …, 2023 - Elsevier
Colorectal tumors often create an immunosuppressive microenvironment that prevents them
from responding to immunotherapy. Cannabidiol (CBD) is a non-psychoactive natural active …

A combined preclinical therapy of cannabinoids and temozolomide against glioma

S Torres, M Lorente, F Rodríguez-Fornés… - Molecular cancer …, 2011 - AACR
Glioblastoma multiforme (GBM) is highly resistant to current anticancer treatments, which
makes it crucial to find new therapeutic strategies aimed at improving the poor prognosis of …

Cannabidiol inhibits RAD51 and sensitizes glioblastoma to temozolomide in multiple orthotopic tumor models

L Soroceanu, E Singer, P Dighe… - Neuro-Oncology …, 2022 - academic.oup.com
Background Cannabidiol (CBD), a nonpsychoactive cannabinoid with a low toxicity profile,
has been shown to produce antitumor activity across cancers in part through selective …