For the clinical application of bone tissue engineering with the combination of biomaterials
and mesenchymal stem cells (MSCs), bone scaffolds should possess excellent …

Sufficient vascularization is quite important for preventing cell death and promoting host
integration during the repair of the critical sized bone defects. Porous structure providing …

Degeneration, trauma, and tumor resection are the main causes of bone loss (Owen et al., J.
Biomed. Mater. Res. B Appl. Biomater. 106 (6), 2493-2512 (2018), Korkusuz et al.,(2014) …

To examine the effect of scaffold pore size on bone regeneration within hydroxyapatite
scaffolds in large segmental defects, this study evaluated two porous interconnected …

Previous studies have proved that dynamic culture could facilitate nutrients transport and
apply mechanical stimulation to the cells within three-dimensional scaffolds, thus enhancing …

Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair
due to its compositional and crystallographic similarity to bioapatites in hard tissues …

Current bone tissue engineering strategies aim to grow a tissue similar to native bone by
combining cells and biologically active molecules with a scaffold material. In this study, a …

The development of biodegradable materials with high osteogenic bioactivity is important for
achieving rapid bone regeneration. Although hydroxyapatite (HAp) has been applied as a …

Nano-sized hydroxyapatite (nanoHA) reinforced composites, mimicking natural bone, were
produced. Examination by transmission electron microscopy revealed that the nanoHA …

Novel tissue engineering scaffold materials of nano-hydroxyapatite (nHA)/silk fibroin (SF)
biocomposite were prepared by freeze-drying. The needle-like nHA crystals of about 10 nm …