The production of'global'metabolite profiles involves measuring low molecular-weight
metabolites (< 1 kDa) in complex biofluids/tissues to study perturbations in response to …

Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

The role of urinary metabolic profiling in systems biology research is expanding. This is
because of the use of this technology for clinical diagnostic and mechanistic studies and for …

Optimisation and method validation was assessed here for metabolic profiling analysis of
urine samples using UPLC–TOFMS. A longer run time of 31min revealed greater …

Urine metabolomics has recently emerged as a prominent field for the discovery of non‐
invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific …

Steps preceding introduction of the analytical sample into individual separation equipment
and/or mass-spectrometry (MS) detectors for targeted or untargeted metabolomics studies …

To better understand the molecular mechanisms underpinning physiological variation in
human populations, metabolic phenotyping approaches are increasingly being applied to …

Obtaining comprehensive, untargeted metabolic profiles for complex solid samples, eg,
animal tissues, requires sample preparation and access to information-rich analytical …

Among all the human biological fluids used for disease biomarker discovery or clinical
chemistry, urine stands out. It can be collected easily and noninvasively, it is readily …

Ultra-performance liquid chromatography coupled to mass spectrometry (UPLC/MS) has
been used increasingly for measuring changes of low molecular weight metabolites in …