Analysis of urine is a widely used diagnostic tool that traditionally measured one or, at most,
a few metabolites. However, the recognition of the need for a holistic approach to …

Background Human urine gives evidence of the metabolism in the body and contains
different metabolites at various concentrations. A number of analytical techniques including …

Currently, most clinical studies in metabolomics only consider a single type of sample such
as urine, plasma, or feces and use a single analytical platform, either NMR or MS. Although …

Self-evidently, research in areas supporting “systems biology” such as genomics,
proteomics, and metabonomics are critically dependent on the generation of sound …

Metabolomics may have the capacity to revolutionize disease diagnosis through the
identification of scores of metabolites that vary during environmental, pathogenic, or …

Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-
to-obtain in large volumes, largely free from interfering proteins or lipids and chemically …

A method for performing untargeted metabolomic analysis of human serum has been
developed based on protein precipitation followed by Ultra Performance Liquid …

Metabolic profiles of biofluids obtained by atmospheric pressure ionization mass
spectrometry-based technologies contain hundreds to thousands of features, most of them …

A strategy combining autocorrelation matrices and ultrahigh resolution mass spectrometry
(MS) was developed to optimize the characterization of discriminating ions highlighted by …

The human metabolome provides a direct physiological read-out of an individual's actual
health state and includes biomarkers that may predict disease or response to a treatment …