NMR-based metabolomics has shown considerable promise in disease diagnosis and
biomarker discovery because it allows one to nondestructively identify and quantify large …

Sample preparation remains a challenge in untargeted metabolomics studies and no
method currently results in complete extraction of all metabolite classes in human plasma …

While metabolomics has tremendous potential for diagnostic biomarker and therapeutic
target discovery, its utility may be diminished by the variability that occurs due to …

Metabolomics is a powerful technique for the discovery of novel biomarkers and elucidation
of biochemical pathways to improve diagnosis, prognosis and therapy. An advantage of this …

Mass spectrometry (MS) is an established technology in drug metabolite analysis and is now
expanding into endogenous metabolite research. Its utility derives from its wide dynamic …

Urine metabolomics is widely used for biomarker research in the fields of medicine and
toxicology. As a consequence, characterization of the variations of the urine metabolome …

Highlights•Metabolomics enables rapid measurements at 10–100 times higher throughput
than proteomics.•The achievable throughput opens entirely new scientific and medical …

High-resolution mass spectrometry (MS) has advanced the study of metabolism in living
systems by allowing many metabolites to be measured in a single experiment. Although …

Urine is a popular biofluid for metabolomics studies due to its simple, non-invasive collection
and its availability in large quantities, permitting frequent sampling, replicate analyses, and …

The metabolome is the terminal downstream product of the genome and consists of the total
complement of all the low‐molecular‐weight molecules (metabolites) in a cell, tissue, or …