Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic
analysis. Leading researchers in the field present protocols for the application of …

For mass spectrometry (MS)-based metabolomics, it is important to use the same amount of
starting materials from each sample to compare the metabolome changes in two or more …

Metabolomics is a technique in which the small molecule component from a biological
source material is analyzed for changes resulting from some set of test conditions. Liquid …

Metabolomics requires quantitative comparison of individual metabolites present in an entire
sample set. Unfortunately, missing intensity values in one or more samples are very …

The metabolome is affected by individual physiologic and pathophysiologic states as well as
the environment. Metabolomics has become crucial approach for clinical studies, providing …

Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …

The process of untargeted metabolic profiling/phenotyping of complex biological matrices,
ie, biological fluids such as blood plasma/serum, saliva, bile, and tissue extracts, provides …

The combination of a new 1.7 μm reversed-phase packing material, and a chromatographic
system, operating at ca. 12 000 psi,(so-called ultra performance liquid chromatography …

Urine metabolites are used in many clinical and biomedical studies but usually only for a few
classic compounds. Metabolomics detects vastly more metabolic signals that may be used to …

Recent advances in mass spectrometry are enabling improved analysis of endogenous
metabolites. Here we discuss several issues relevant to developing liquid chromatography …