Recent advances in mass spectrometry are enabling improved analysis of endogenous
metabolites. Here we discuss several issues relevant to developing liquid chromatography …

Urine metabolites are used in many clinical and biomedical studies but usually only for a few
classic compounds. Metabolomics detects vastly more metabolic signals that may be used to …

Metabolic profiling, metabolomic and metabonomic studies mainly involve the
multicomponent analysis of biological fluids, tissue and cell extracts using NMR …

Highlights•Metabolomics provides a very powerful tool in pharmaceutical and clinical
research.•Metabolomic biomarkers can improve personalized treatments.•Metabolomics can …

Metabolomics has emerged in the past decade as a highly attractive and impactful
technique for phenotype-level profiling in diverse biological applications. Most recently, the …

Continuing improvements in analytical technology along with an increased interest in
performing comprehensive, quantitative metabolic profiling, is leading to increased interest …

Mass spectrometry (MS) has secured a central role in metabolomics that is predicted to grow
based upon continuous developments and improvements in MS technologies. This article …

Large-scale metabolomics study requires a quantitative method to generate metabolome
data over an extended period with high technical reproducibility. We report a universal …

Untargeted, global metabolite profiling (often described as metabonomics or metabolomics)
represents an expanding research topic and is, potentially, a major pillar for systems biology …

Extraction of meaningful biological information from urinary metabolomic profiles obtained
by liquid-chromatography coupled to mass spectrometry (MS) necessitates the control of …