Advances in mass spectrometry-based multi-scale metabolomic methodologies and their applications in biological and clinical investigations

Z Wang, H Zhu, W Xiong - Science Bulletin, 2023 - Elsevier
Metabolomics is a nascent field of inquiry that emerged in the late 20 th century. It
encompasses the comprehensive profiling of metabolites across a spectrum of organisms …

Interlaboratory reproducibility of a targeted metabolomics platform for analysis of human serum and plasma

AP Siskos, P Jain, W Römisch-Margl… - Analytical …, 2017 - ACS Publications
A critical question facing the field of metabolomics is whether data obtained from different
centers can be effectively compared and combined. An important aspect of this is the …

[HTML][HTML] GC–MS libraries for the rapid identification of metabolites in complex biological samples

N Schauer, D Steinhauser, S Strelkov, D Schomburg… - FEBS letters, 2005 - Elsevier
Gas chromatography–mass spectrometry based metabolite profiling of biological samples is
rapidly becoming one of the cornerstones of functional genomics and systems biology. Thus …

Utility of separation science in metabolomic studies

HJ Issaq, E Abbott, TD Veenstra - Journal of Separation …, 2008 - Wiley Online Library
Metabolomics, or alternately metabonomics, an emerging field of biochemical research, is a
complementary technique to genomics, transcriptomics, and proteomics. Direct quantitative …

Strategies for large-scale targeted metabolomics quantification by liquid chromatography-mass spectrometry

J Zhou, Y Yin - Analyst, 2016 - pubs.rsc.org
Advances in liquid chromatography-mass spectrometry (LC-MS) instruments and analytical
strategies have brought about great progress in targeted metabolomics analysis. This …

Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review

A Roux, D Lison, C Junot, JF Heilier - Clinical biochemistry, 2011 - Elsevier
The metabolome is the set of small molecular mass organic compounds found in a given
biological media. It includes all organic substances naturally occurring from the metabolism …

Metabolite profiling in blood plasma

O Fiehn, T Kind - Metabolomics: Methods and protocols, 2007 - Springer
Metabolite profiling has been established as a multiparallel strategy for relative
quantification of a mixture of compounds or compound classes using chromatography and …

[HTML][HTML] Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and …

K Contrepois, L Jiang, M Snyder - Molecular & Cellular Proteomics, 2015 - ASBMB
Profiling of body fluids is crucial for monitoring and discovering metabolic markers of health
and disease and for providing insights into human physiology. Since human urine and …

Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids

HFN Kvitvang, T Andreassen, T Adam… - Analytical …, 2011 - ACS Publications
Metabolite profiling methods are important tools for measurement of metabolite pools in
biological systems. While most metabolite profiling methods report relative intensities or …

[HTML][HTML] Assessment of human plasma and urine sample preparation for reproducible and high-throughput UHPLC-MS clinical metabolic phenotyping

AD Southam, LD Haglington, L Najdekr, A Jankevics… - Analyst, 2020 - pubs.rsc.org
Clinical metabolic phenotyping employs metabolomics and lipidomics to detect and
measure hundreds to thousands of metabolites and lipids within human samples. This …