Abstract 1 H NMR metabolic profiling of urine, serum and plasma has been used to monitor
the impact of the pre-analytical steps on the sample quality and stability in order to propose …

Background: Metabolomics is increasingly recognized as an invaluable tool in the
biological, medical and environmental sciences yet lags behind the methodological maturity …

Metabolite profiling methods are important tools for measurement of metabolite pools in
biological systems. While most metabolite profiling methods report relative intensities or …

Target-based metabolomics, focused on a subset of metabolites representative of key
pathways, is a valuable tool for assessing metabolic changes resulting from genetic …

Targeted detection is one of the most important methods in mass spectrometry (MS)-based
metabolomics; however, its major limitation is the reduced metabolome coverage that results …

A method for the preparation and GC− TOF-MS analysis of human serum samples has been
developed and evaluated for application in long-term metabolomic studies. Serum samples …

Analytical techniques used for multivariate analysis of endogenous metabolites in biological
systems (eg, metabolomics, metabonomics) must be capable of accurately and selectively …

Hydrophilic interaction ultra performance liquid chromatography (HILIC-UPLC) permits the
analysis of highly polar metabolites, providing complementary information to reversed …

Introduction We previously developed a tandem mass spectrometry-based label-free
targeted metabolomics analysis framework coupled to two distinct chromatographic …

Urine is often sampled from patients participating in clinical and metabolomic studies.
Biological homeostasis occurs in humans, but little is known about the variability of …