[HTML][HTML] Antidiabetic effect of salvianolic acid A on diabetic animal models via AMPK activation and mitochondrial regulation

G Qiang, X Yang, L Shi, H Zhang, B Chen… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: Diabetes mellitus (DM) characterized by hyperglycemia contributes to
macrovascular and microvascular complications. Salvianolic acid A (SalA) is a polyphenolic …

[HTML][HTML] Salvianolic acid B ameliorates hyperglycemia and dyslipidemia in db/db mice through the AMPK pathway

MQ Huang, CJ Zhou, YP Zhang, XQ Zhang… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Salvianolic acid B (Sal B), a major polyphenolic compound of Salvia
miltiorrhiza Bunge, has been shown to possess potential antidiabetic activities. However, the …

Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway

J Sun, P Leng, X Li, Q Guo, J Zhao, Y Liang, X Zhang… - Adipocyte, 2022 - Taylor & Francis
Mitochondrial dysfunction is associated with insulin resistance and type 2 diabetes (T2DM).
Decreased mitochondrial abundance and function were found in white adipose tissue (WAT) …

[HTML][HTML] Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy

D Gong, S Sun, R Wang, A Dawuti, D Kong… - Biomedicine & …, 2023 - Elsevier
Salvianolic acid A (SAA) is a traditional Chinese medicine that has a good therapeutic effect
on cardiovascular disease. However, the underlying mechanisms by which SAA improves …

Salvianolic acid B alleviates diabetic endothelial and mitochondrial dysfunction by down-regulating apoptosis and mitophagy of endothelial cells

J Xiang, C Zhang, T Di, L Chen, W Zhao, L Wei… - …, 2022 - Taylor & Francis
Endothelial dysfunction is a critical mediator in the pathogenesis of vascular complications
of diabetes. Herein, this study was conducted to investigate the therapeutic effects of …

Salidroside ameliorates insulin resistance through activation of a mitochondria‐associated AMPK/PI3K/A kt/GSK 3β pathway

T Zheng, X Yang, D Wu, S Xing, F Bian… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Recent reports have suggested that salidroside could protect
cardiomyocytes from oxidative injury and stimulate glucose uptake in skeletal muscle cells …

Inhibition of glucose-induced vascular endothelial growth factor expression by Salvia miltiorrhiza hydrophilic extract in human microvascular endothelial cells …

S Qian, D Huo, S Wang, Q Qian - Journal of Ethnopharmacology, 2011 - Elsevier
AIM OF STUDY: Diabetes mellitus is frequently combined with vascular diseases, which are
associated with the expression of vascular endothelial growth factor (VEGF). An approach …

Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3

Y Li, X Wei, SL Liu, Y Zhao, S Jin… - Phytotherapy …, 2021 - Wiley Online Library
To investigate the effects and the underlying mechanisms of salidroside on diabetic
cardiomyopathy, diabetes was induced in mice by a long‐term high‐fat diet and a low‐dose …

Salvianolic acid A protects the peripheral nerve function in diabetic rats through regulation of the AMPK-PGC1α-Sirt3 axis

X Yu, L Zhang, X Yang, H Huang, Z Huang, L Shi… - Molecules, 2012 - mdpi.com
Salvianolic acid A (SalA) is one of the main efficacious, water-soluble constituents of Salvia
miltiorrhiza Bunge. This study investigated the protective effects of SalA on peripheral nerve …

D-saccharic acid-1, 4-lactone ameliorates alloxan-induced diabetes mellitus and oxidative stress in rats through inhibiting pancreatic beta-cells from apoptosis via …

S Bhattacharya, P Manna, R Gachhui, PC Sil - Toxicology and Applied …, 2011 - Elsevier
Oxidative stress plays a vital role in diabetic complications. To suppress the oxidative stress
mediated damage in diabetic pathophysiology, a special focus has been given on naturally …