[HTML][HTML] The importance of global studies of the genetics of type 2 diabetes

MI McCarthy - Diabetes & Metabolism Journal, 2011 - synapse.koreamed.org
Genome wide association analyses have revealed large numbers of common variants
influencing predisposition to type 2 diabetes and related phenotypes. These studies have …

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

CC Robertson, JRJ Inshaw, S Onengut-Gumuscu… - Nature …, 2021 - nature.com
We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date
(61,427 participants), yielding 78 genome-wide-significant (P< 5× 10− 8) regions, including …

[HTML][HTML] Type 2 diabetes genetics: beyond GWAS

DK Sanghera, PR Blackett - Journal of diabetes & metabolism, 2012 - ncbi.nlm.nih.gov
The global epidemic of type 2 diabetes mellitus (T2D) is one of the most challenging
problems of the 21 st century leading cause of and the fifth death worldwide. Substantial …

Recent advances in understanding the genetic architecture of type 2 diabetes

KL Mohlke, M Boehnke - Human molecular genetics, 2015 - academic.oup.com
Genome-wide association (GWAS) and sequencing studies are providing new insights into
the genetic basis of type 2 diabetes (T2D) and the inter-individual variation in glycemic traits …

A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations

X Wang, X Liu, X Sim, H Xu, CC Khor… - European journal of …, 2012 - nature.com
Genome-wide association studies (GWAS) have become the preferred experimental design
in exploring the genetic etiology of complex human traits and diseases. Standard SNP …

Genetics of type 2 diabetes

MI McCarthy, E Zeggini - Current diabetes reports, 2006 - Springer
After several years of uncertain progress, the stage is now set for a transformation in
understanding the genetic landscape of type 2 diabetes. Advances in genome informatics …

In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium

HQ Qu, JP Bradfield, Q Li, C Kim… - Human molecular …, 2010 - academic.oup.com
Abstract Recently, the Type 1 Diabetes Genetics Consortium (T1DGC) reported 22 novel
type 1 diabetes (T1D)-associated loci identified by meta-analysis of three genome-wide …

Identification of type 2 diabetes loci in 433,540 East Asian individuals

CN Spracklen, M Horikoshi, YJ Kim, K Lin, F Bragg… - Nature, 2020 - nature.com
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …

The genetics of type 2 diabetes: a realistic appraisal in 2008

JC Florez - The Journal of Clinical Endocrinology & Metabolism, 2008 - academic.oup.com
Context: Over the last few months, genome-wide association studies have contributed
significantly to our understanding of the genetic architecture of type 2 diabetes. If and how …

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

J Flannick, JM Mercader, C Fuchsberger, MS Udler… - bioRxiv, 2018 - biorxiv.org
Protein-coding genetic variants that strongly affect disease risk can provide important clues
into disease pathogenesis. Here we report an exome sequence analysis of 20,791 type 2 …