The aim was to evaluate the effects and mechanisms of nebivolol on renal damage in
Zucker diabetic fatty (ZDF) rats, in comparison with those of atenolol and captopril. Animals …

Objective Atenolol, a first-generation β-blocker, effectively reduces blood pressure, although
its use in metabolic syndrome remains controversial. Accordingly, this study evaluated the …

Background To evaluate the protective effect of nebivolol against kidney damage and
elucidate the underlying mechanism in a two-kidney, one-clip (2K1C) rat model. Methods …

This study aims to decipher the potential effects of nebivolol in prevention and/or regression
of renal artery dysfunction in diabetes associated with hypertension. Renal arteries were …

Background Although effective in reducing blood pressure, therapy with a first-generation β-
blocker is currently controversial in metabolic syndrome due to its negative impact on …

Oxidative stress plays an important role in the pathogenesis of diabetic nephropathy. The β‐
blocker carvedilol has been proven to have an anti‐oxidant property. The aim of the present …

We studied whether the β 1-adrenergic antagonist nebivolol would prevent ethanol-induced
reactive oxygen species generation and lipoperoxidation in the rat renal cortex. Male Wistar …

Introduction Chronic hyperglycemia-induced oxidative stress plays a crucial role in the
development of diabetic nephropathy (DN). Moreover, adverse extracellular matrix (ECM) …

Background/Aims: Increased oxidative stress is involved in the aetiology of diabetic
nephropathy, and angiotensin II is reported to play a considerable role in the development of …

This study was conducted to investigate whether the renoprotective effects of fenofibrate are
mediated via attenuation of endothelial dysfunction and modulating the mRNA expression of …