Background Vascular endothelial growth factor (VEGF) expression is up-regulated via a
cyclooxygenase-2 (COX-2)-dependent mechanism in non-small cell lung cancer (NSCLC) …

Abstract Background Cyclooxygenase (COX)-2 has been implicated in tumour progression,
angiogenesis and metastasis in non-small cell lung cancer (NSCLC). We speculated that …

Interaction between cancer cells and adjacent stromal cells is important to promote tumor
development. Our aim was to study total COX‐2 mRNA expression in both cancer cells and …

The role of COX-2 expression and angiogenesis of lung cancer is yet to be delineated.
Eighty four non-small cell lung cancer (NSCLC) specimens were evaluated for COX-2 …

Abstract Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin H synthase, has
been implicated in the progression of human lung adenocarcinoma. However, the …

The objective of the present study was to investigate whether cyclooxygenase-2 (COX-2) is
associated with malignancy, and to investigate its molecular mechanisms in human lung …

Both cyclooxygenase (COX)-2 and epidermal growth factor receptor (EGFR) are thought to
play important roles in the pathogenesis of non-small cell lung cancer (NSCLC). A number …

Evidence is accumulating to suggest that the inducible isoenzyme of cyclooxygenase (COX)-
2 is up-regulated in human cancers and epidemiological studies indicate that COX inhibitors …

Preclinical studies suggest that cyclooxygenase (COX)-2 may be involved in the molecular
pathogenesis of some types of lung cancer. Most of the available studies point to its …

Vascular endothelial growth factor (VEGF) plays a critical role in tumor progression,
angiogenesis and metastasis. Cyclooxygenase (COX)-2, matrix metalloproteinase (MMP) 2 …