New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease
M Medina, J Avila - Expert opinion on therapeutic targets, 2014 - Taylor & Francis
Introduction: Glycogen synthase kinase-3 (GSK-3) is recognized as a crucial player in many
cellular functions and its activity is tightly controlled by complex mechanisms that are each …
cellular functions and its activity is tightly controlled by complex mechanisms that are each …
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
CA Grimes, RS Jope - Progress in neurobiology, 2001 - Elsevier
Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine …
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine …
In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors
P De Sarno, GN Bijur, AA Zmijewska, X Li… - Neurobiology of aging, 2006 - Elsevier
Glycogen synthase kinase-3 (GSK3), which is inhibited by serine-phosphorylation, is
involved in the neuropathology of Alzheimer's disease (AD). We tested if the two therapeutic …
involved in the neuropathology of Alzheimer's disease (AD). We tested if the two therapeutic …
Phosphorylation of threonine-19 of PSD-95 by GSK-3β is required for PSD-95 mobilization and long-term depression
CD Nelson, MJ Kim, H Hsin, Y Chen… - Journal of …, 2013 - Soc Neuroscience
Activity of glycogen synthase kinase-3β (GSK-3β) is required for long-term depression (LTD)
via molecular mechanisms that are incompletely understood. Here, we report that PSD-95, a …
via molecular mechanisms that are incompletely understood. Here, we report that PSD-95, a …
The GSK3 hypothesis of Alzheimer's disease
C Hooper, R Killick, S Lovestone - Journal of neurochemistry, 2008 - Wiley Online Library
J. Neurochem.(2008) 104, 1433–1439. Abstract Glycogen synthase kinase 3 (GSK3) is a
constitutively active, proline‐directed serine/threonine kinase that plays a part in a number of …
constitutively active, proline‐directed serine/threonine kinase that plays a part in a number of …
GSK3 in Alzheimer's disease: mind the isoforms
T Ma - Journal of Alzheimer's Disease, 2014 - content.iospress.com
Understanding the molecular signaling pathways that go awry in Alzheimer's disease (AD)
would provide insights into developing novel therapies for this devastating …
would provide insights into developing novel therapies for this devastating …
Glycogen synthase kinase‐3 inhibition prevents learning deficits in diabetic mice
MR King, NJ Anderson, LS Guernsey… - Journal of …, 2013 - Wiley Online Library
There is an increasing awareness that diabetes has an impact on the central nervous
system, with reports of impaired learning, memory, and mental flexibility being more …
system, with reports of impaired learning, memory, and mental flexibility being more …
Glycogen synthase kinase 3 regulates N-methyl-D-aspartate receptor channel trafficking and function in cortical neurons
P Chen, Z Gu, W Liu, Z Yan - Molecular pharmacology, 2007 - ASPET
Emerging evidence has suggested that glycogen synthase kinase 3 (GSK-3) is a key
regulatory kinase involved in a plethora of processes in the nervous system, including …
regulatory kinase involved in a plethora of processes in the nervous system, including …
Age-related changes in glycogen synthase kinase 3β (GSK3β) immunoreactivity in the central nervous system of rats
Although glycogen synthase kinase 3β (GSK3β) is emerging as a prominent drug target in
the treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and stroke …
the treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and stroke …
Anesthesia and post‐mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase‐3 in mouse brain
X Li, AB Friedman, MS Roh… - Journal of …, 2005 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3) is a crucial enzyme contributing to the
regulation of neuronal structure, plasticity and survival, is implicated as a contributory factor …
regulation of neuronal structure, plasticity and survival, is implicated as a contributory factor …