Abnormal tau phosphorylation resulting in detachment of tau from microtubules and
aggregation are critical events in neuronal dysfunction, degeneration, and neurofibrillary …

Alzheimer's disease (AD) is a common neurodegenerative disorder that presents clinically
as inexorable cognitive impairment and decline in performance of activities of daily living …

Amyloid deposits, neurofibrillary tangles, and neuronal cell death in selectively vulnerable
brain regions are the chief hallmarks in Alzheimer's (AD) brains. Glycogen synthase kinase …

Glycogen synthase kinase-3β (GSK-3β) is thought to mediate morphological responses to a
variety of extracellular signals. Surprisingly, we found no gross morphological deficits in …

Glycogen synthase kinase-3 (GSK-3) is linked to the pathogenesis of Alzheimer's disease
(AD), senile plaques (SPs), and neurofibrillary tangles (NFTs), but the specific contributions …

β-Amyloid (Aβ) plaques in Alzheimer (AD) brains are surrounded by severe dendritic and
axonal changes, including local spine loss, axonal swellings and distorted neurite …

Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …

Abstract Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of
Alzheimer's disease (AD). GSK-3β is involved in the formation of paired helical filament …

Adult hippocampal neurogenesis (AHN) is crucial for the maintenance of hippocampal
function. Several neurodegenerative diseases such as Alzheimer's disease (AD) are …

Abstract Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the
CNS. The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's …