Introduction: Adult epidermal stem cells are crucial for skin tissue regeneration during
homeostasis and disease. Recent updates relating to the function, cellular role and …

This is a chronicle of concepts in the field of epidermal stem cell biology and a historic look
at their development over time. The past 25 years have seen the evolution of epidermal stem …

The epidermis is a self-renewing tissue which regenerates constantly. It consists mainly of
keratinocytes of various degree of differentiation, from the proliferative basal layer to the …

Stem cells are involved in the renewal and regeneration of the epithelium of various organs.
The largest reservoir of epithelial stem cells in the human body is the skin. This organ is a …

The identification of adult epidermal stem cells that are capable of self‐renewal and can
reconstitute not only the epidermis but also the cutaneous appendages opens new …

The field of epidermal stem cells has dramatically advanced in the last decade, leading to a
better understanding of the molecular factors, signalling pathways and cellular events that …

Stem cells present in the epidermis, and hair follicle, guarantee the conservation of adult
skin maintenance and hair renewal, but they also play a pivotal role in wound repair and …

Skin and squamous epithelia regulate water and heat homeostasis and constitute our first
barrier of protection against pathogens. Cells from the outermost layer of the skin, the …

Recent studies are beginning to reveal that our basic concepts of epidermal stem cell
biology may be based on somewhat tenuous ground. For example, it is often assumed that …

A multilayered epithelium to fulfil its function must be replaced throughout the lifespan. This
is possible due to the presence of multipotent, self-renewing epidermal stem cells that give …