An amino‐terminal threonine/serine motif is necessary for activity of the Crp/Fnr homolog, MrpC and for Myxococcus xanthus developmental robustness
BE Feeley, V Bhardwaj, M McLaughlin… - Molecular …, 2019 - Wiley Online Library
Summary The Crp/Fnr family of transcriptional regulators play central roles in transcriptional
control of diverse physiological responses, and are activated by a surprising diversity of …
control of diverse physiological responses, and are activated by a surprising diversity of …
MrpC, a CRP/Fnr homolog, functions as a negative autoregulator during the Myxococcus xanthus multicellular developmental program
M McLaughlin, V Bhardwaj, BE Feeley… - Molecular …, 2018 - Wiley Online Library
MrpC, a member of the CRP/Fnr superfamily of transcriptional regulators, plays a key role in
coordination of the multicellular developmental program in Myxococcus xanthus. Previous …
coordination of the multicellular developmental program in Myxococcus xanthus. Previous …
A protein Ser/Thr kinase cascade negatively regulates the DNA‐binding activity of MrpC, a smaller form of which may be necessary for the Myxococcus xanthus …
H Nariya, S Inouye - Molecular microbiology, 2006 - Wiley Online Library
The developmental process of Myxococcus xanthus is achieved by the expression of a
specific set of genes under the influence of developmental signals. MrpC is a member of the …
specific set of genes under the influence of developmental signals. MrpC is a member of the …
[HTML][HTML] Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus
M Robinson, B Son, D Kroos, L Kroos - BMC genomics, 2014 - Springer
Background Myxococcus xanthus is a bacterium that undergoes multicellular development
when starved. Cells move to aggregation centers and form fruiting bodies in which cells …
when starved. Cells move to aggregation centers and form fruiting bodies in which cells …
[HTML][HTML] Mutation of self-binding sites in the promoter of the MrpC transcriptional regulator leads to asynchronous Myxococcus xanthus development
M McLaughlin, PI Higgs - Frontiers in Microbiology, 2023 - frontiersin.org
Introduction MrpC, a member of the CRP/Fnr transcription factor superfamily, is necessary to
induce and control the multicellular developmental program of the bacterium, Myxococcus …
induce and control the multicellular developmental program of the bacterium, Myxococcus …
Characterization of the role of MrpC in Myxococcus xanthus developmental cell fate determination
V Bhardwaj - 2013 - archiv.ub.uni-marburg.de
Myxococcus xanthus is an excellent model system for multicellular prokaryotic behaviour
and Gram-negative differentiation. Under nutrient-limited conditions, the population enters a …
and Gram-negative differentiation. Under nutrient-limited conditions, the population enters a …
Identification of a protein Ser/Thr kinase cascade that regulates essential transcriptional activators in Myxococcus xanthus development
H Nariya, S Inouye - Molecular microbiology, 2005 - Wiley Online Library
Pkn8 is a membrane‐associated protein Ser/Thr kinase (PSTK) of Myxoccocus xanthus that
was previously found to associate with a novel cytoplasmic kinase, Pkn14. In the present …
was previously found to associate with a novel cytoplasmic kinase, Pkn14. In the present …
A combination of unusual transcription factors binds cooperatively to control Myxococcus xanthus developmental gene expression
S Mittal, L Kroos - Proceedings of the National Academy of …, 2009 - National Acad Sciences
Myxococcus xanthus is a bacterium that undergoes multicellular development requiring
coordinate regulation of multiple signaling pathways. One pathway governs aggregation …
coordinate regulation of multiple signaling pathways. One pathway governs aggregation …
Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria
S Ranganathan, J Cheung, M Cassidy… - Nucleic acids …, 2018 - academic.oup.com
Mycobacterium tuberculosis (Mtb) encodes two CRP/FNR family transcription factors (TF)
that contribute to virulence, Cmr (Rv1675c) and CRPMt (Rv3676). Prior studies identified …
that contribute to virulence, Cmr (Rv1675c) and CRPMt (Rv3676). Prior studies identified …
A negative autoregulation network motif is required for synchronized Myxococcus xanthus development
M McLaughlin, PI Higgs - bioRxiv, 2019 - biorxiv.org
Transcription factor autoregulation is a simple network motif (recurring circuit) built into
genetic regulatory networks that direct cell behavior. Negative autoregulation (NAR) network …
genetic regulatory networks that direct cell behavior. Negative autoregulation (NAR) network …