Gamete-level immunogenetic incompatibility in humans–towards deeper understanding of fertilization and infertility?
Human leukocyte antigen (HLA) immune genes play an important role in partner selection,
but it has remained unclear if nonrandom pairing with respect to parental HLA genes could …
but it has remained unclear if nonrandom pairing with respect to parental HLA genes could …
Structural dissimilarity of partners' immune genes increases sperm viability in women's reproductive tract
M Magris, A Jokiniemi, L Kuusipalo… - Journal of …, 2021 - academic.oup.com
Human leucocyte antigen (HLA) genes appear to mediate pre‐and post‐copulatory mate
choice towards HLA‐dissimilar ('compatible') partners. However, since genetically distinct …
choice towards HLA‐dissimilar ('compatible') partners. However, since genetically distinct …
Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function
Several studies have demonstrated that women show pre-copulatory mating preferences for
human leucocyte antigen (HLA)-dissimilar men. A fascinating, yet unexplored, possibility is …
human leucocyte antigen (HLA)-dissimilar men. A fascinating, yet unexplored, possibility is …
Evidence for major histocompatibility complex-mediated effects on spermatogenesis in humans
K Van der Ven, R Fimmers, G Engels… - Human …, 2000 - academic.oup.com
Studies in fertile and infertile populations suggest an influence of genes of the major
histocompatibility complex (MHC) on reproduction, although it remains unresolved if MHC …
histocompatibility complex (MHC) on reproduction, although it remains unresolved if MHC …
Genetic incompatibility of the reproductive partners: an evolutionary perspective on infertility
J Kekäläinen - Human Reproduction, 2021 - academic.oup.com
In natural fertilisation, the female reproductive tract allows only a strictly selected sperm
subpopulation to proceed in the vicinity of an unfertilised oocyte. Female-mediated sperm …
subpopulation to proceed in the vicinity of an unfertilised oocyte. Female-mediated sperm …
Genetic Considerations in Human Sex‐Mate Selection: Partners Share Human Leukocyte Antigen but not Short‐Tandem‐Repeat Identity Markers
M Israeli, D Kristt, Y Nardi, T Klein - American Journal of …, 2014 - Wiley Online Library
Problem Previous studies support a role for MHC on mating preference, yet it remains
unsettled as to whether mating occurs preferentially between individuals sharing human …
unsettled as to whether mating occurs preferentially between individuals sharing human …
The enigmatic interplay of immune cells and abnormal spermatozoa through Mendelian randomization
F Zheng, S Li, Z Wang, S Xiong, J Liu… - American Journal of …, 2024 - Wiley Online Library
Purpose Abnormal spermatozoa significantly impact reproductive health, affecting fertility
rates, potentially prolonging conception time, and increasing the risk of miscarriages. This …
rates, potentially prolonging conception time, and increasing the risk of miscarriages. This …
Cryptic female choice favours sperm from major histocompatibility complex-dissimilar males
H Løvlie, MAF Gillingham, K Worley… - … of the Royal …, 2013 - royalsocietypublishing.org
Cryptic female choice may enable polyandrous females to avoid inbreeding or bias offspring
variability at key loci after mating. However, the role of these genetic benefits in cryptic …
variability at key loci after mating. However, the role of these genetic benefits in cryptic …
[图书][B] Immune infertility
WKH Krause, RK Naz - 2009 - Springer
Infertility is defined as an inability to conceive after unprotected intercourse for a year.
Infertility is increasing worldwide and has various causes, which occur in the male and/or …
Infertility is increasing worldwide and has various causes, which occur in the male and/or …
Deleterious impact of feto-maternal MHC compatibility on the success of pregnancy in a macaque model
A Aarnink, ET Mee, N Savy, N Congy-Jolivet, NJ Rose… - Immunogenetics, 2014 - Springer
The impact of feto-maternal histocompatibility on reproduction has inspired long-lasting
debates. However, after the review of numerous articles, the impact of HLA allele sharing …
debates. However, after the review of numerous articles, the impact of HLA allele sharing …