Gamete-level immunogenetic incompatibility in humans–towards deeper understanding of fertilization and infertility?

A Jokiniemi, L Kuusipalo, J Ritari, S Koskela… - Heredity, 2020 - nature.com
Human leukocyte antigen (HLA) immune genes play an important role in partner selection,
but it has remained unclear if nonrandom pairing with respect to parental HLA genes could …

Structural dissimilarity of partners' immune genes increases sperm viability in women's reproductive tract

M Magris, A Jokiniemi, L Kuusipalo… - Journal of …, 2021 - academic.oup.com
Human leucocyte antigen (HLA) genes appear to mediate pre‐and post‐copulatory mate
choice towards HLA‐dissimilar ('compatible') partners. However, since genetically distinct …

Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function

A Jokiniemi, M Magris, J Ritari… - … of the Royal …, 2020 - royalsocietypublishing.org
Several studies have demonstrated that women show pre-copulatory mating preferences for
human leucocyte antigen (HLA)-dissimilar men. A fascinating, yet unexplored, possibility is …

Evidence for major histocompatibility complex-mediated effects on spermatogenesis in humans

K Van der Ven, R Fimmers, G Engels… - Human …, 2000 - academic.oup.com
Studies in fertile and infertile populations suggest an influence of genes of the major
histocompatibility complex (MHC) on reproduction, although it remains unresolved if MHC …

Genetic incompatibility of the reproductive partners: an evolutionary perspective on infertility

J Kekäläinen - Human Reproduction, 2021 - academic.oup.com
In natural fertilisation, the female reproductive tract allows only a strictly selected sperm
subpopulation to proceed in the vicinity of an unfertilised oocyte. Female-mediated sperm …

Genetic Considerations in Human Sex‐Mate Selection: Partners Share Human Leukocyte Antigen but not Short‐Tandem‐Repeat Identity Markers

M Israeli, D Kristt, Y Nardi, T Klein - American Journal of …, 2014 - Wiley Online Library
Problem Previous studies support a role for MHC on mating preference, yet it remains
unsettled as to whether mating occurs preferentially between individuals sharing human …

The enigmatic interplay of immune cells and abnormal spermatozoa through Mendelian randomization

F Zheng, S Li, Z Wang, S Xiong, J Liu… - American Journal of …, 2024 - Wiley Online Library
Purpose Abnormal spermatozoa significantly impact reproductive health, affecting fertility
rates, potentially prolonging conception time, and increasing the risk of miscarriages. This …

Cryptic female choice favours sperm from major histocompatibility complex-dissimilar males

H Løvlie, MAF Gillingham, K Worley… - … of the Royal …, 2013 - royalsocietypublishing.org
Cryptic female choice may enable polyandrous females to avoid inbreeding or bias offspring
variability at key loci after mating. However, the role of these genetic benefits in cryptic …

[图书][B] Immune infertility

WKH Krause, RK Naz - 2009 - Springer
Infertility is defined as an inability to conceive after unprotected intercourse for a year.
Infertility is increasing worldwide and has various causes, which occur in the male and/or …

Deleterious impact of feto-maternal MHC compatibility on the success of pregnancy in a macaque model

A Aarnink, ET Mee, N Savy, N Congy-Jolivet, NJ Rose… - Immunogenetics, 2014 - Springer
The impact of feto-maternal histocompatibility on reproduction has inspired long-lasting
debates. However, after the review of numerous articles, the impact of HLA allele sharing …