Our understanding of IBD pathogenesis has been increasing rapidly. The genetically
determined interplay between the commensal microbiota, intestinal epithelial cells, and the …

For over half a century, and despite progressively intensified research efforts, the etiology of
inflammatory bowel disease remains an enigma. The most widely accepted comprehensive …

During my biochemistry degree I became fascinated by the complexity and wonder of the
immune system. How in the vast majority of us it steadfastly protects from pathogens but in …

The intestinal immune system has to discriminate between harmful and beneficial antigens.
Although strong protective immunity is essential to prevent invasion by pathogens …

Rare, monogenetic diseases present unique models to dissect gene functions and
biological pathways, concomitantly enhancing our understanding of the etiology of complex …

A great deal of research into the pathogenesis of inflammatory bowel disease (IBD) has
painted a picture of a dysregulated adaptive immune response to the presence of luminal …

The innate immune system plays a crucial role in maintaining the integrity of the intestine
and protecting the host against a vast number of potential microbial pathogens from resident …

Recent advances have highlighted the complex mechanistics and functional diversity of
innate immunity that paradoxically mediate both protective and destructive responses in the …

Inflammatory bowel diseases are characterized by chronic intestinal inflammation at different
sites. Data from animal models as well as human patients including gene-association …

Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between
sometimes hostile external environments and the internal milieu. However, mucosae are …