Recent progresses in the immune mechanisms implicated in chronic inflammatory disorders
have led to a more in-depth knowledge of the pathogenesis of autoimmune diseases of the …

Publisher Summary The intestinal mucosa can pose a considerable risk if not kept under
very tight control, as is clearly illustrated by the severe intestinal pathology that often …

The intestinal epithelium—which constitutes the interface between the enteric microbiota
and host tissues—actively contributes to the maintenance of mucosal homeostasis and …

Inflammatory bowel diseases (IBD) provide a complex model of host-microbe interactions
underpinning disease pathogenesis. Although there is no widespread agreement on the …

Inflammatory bowel disease (IBD) results from a continuum of complex interactions between
a quartet of host-derived and external elements that involve various aspects of the intestinal …

Abnormal response to enteric microflora is a critical factor driving bowel inflammation in
patients with inflammatory bowel disease (IBD). Mice with genetically engineered mutations …

In this review, the role of innate and adaptive immunity in the pathogenesis of inflammatory
bowel diseases (IBD) is reported. In IBD, an altered innate immunity is often found, with …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder caused by
dysregulated immune responses in a genetically predisposed individual. Recent …

The gastrointestinal tract is continuously exposed to foreign antigens—mainly derived from
the commensal microbiota and food antigens—but occasionally to those derived from …

The human body is densely colonized by more than a trillion of commensal and mutualistic
microorganisms, including archaea, bacteria, virus, bacteriophages and fungi (1–3). The …