The intestine represents the largest compartment of the immune system. It is continually
exposed to antigens and immunomodulatory agents from the diet and the commensal …

Immune‐mediated inflammatory diseases (IMIDs) are a diverse group of complex
inflammatory diseases that result from dysregulated immune pathways and can involve any …

Inflammatory bowel disease (IBD) results from a complex series of interactions between
susceptibility genes, the environment, and the immune system. The host microbiome, as well …

Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …

The mucosal interstitia of the intestine and colon are continuously exposed to large amounts
of dietary and microbial antigens. Fortunately, the mucosal immune system has evolved …

In recent years the status of the inflammatory bowel diseases (IBDs) as canonical
autoimmune diseases has risen steadily with the recognition that these diseases are, at their …

Crohn's disease (CD) and ulcerative colitis (UC) are the two most common forms of chronic
inflammatory bowel disease (IBD). The etiology of IBD is still unclear and should be …

Intestinal homeostasis depends on complex interactions between the microbiota, the
intestinal epithelium and the host immune system. Diverse regulatory mechanisms …

Inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis
(UC), are chronic inflammatory autoimmune conditions of the gastrointestinal tract. Other …