The clustered regularly interspaced short palindromic repeat (CRISPR) system has been
widely adapted to genome editing to either introduce or correct genetic mutations (Wang et …

Many human genetic diseases are caused by pathogenic single nucleotide mutations.
Animal models are often used to study these diseases where the pathogenic point mutations …

CRISPR/Cas9 is a powerful tool for genome editing (Komor et al., 2017). Recently, it has
been employed in several attempts to edit the human embryos (Liang et al., 2015; Kang et …

Cytidine base editors (CBEs) and adenine base editors (ABEs), composed of a cytidine
deaminase or an evolved adenine deaminase fused to Cas9 nickase, enable the conversion …

Cytosine base editors (CBEs) efficiently generate precise C· G-to-T· A base conversions, but
the activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme catalytic …

Base editors have substantial promise in basic research and as therapeutic agents for the
correction of pathogenic mutations. The development of adenine transversion editors has …

Cytidine and adenosine deaminases are required for cytosine and adenine editing of base
editors respectively, and no single deaminase could enable concurrent and comparable …

There are hundreds of disease-causing single-gene mutations, mainly caused by single-
nucleotide substitutions or point mutations rather than small insertions/deletions (indels) …

Deaminase base editing has emerged as a tool to install or correct point mutations in the
genomes of living cells in a wide range of organisms. However, the genome-wide off-target …

Genome editing using programmable nucleases such as CRISPR/Cas9 or Cpf1 has
emerged as powerful tools for gene knock-out or knock-in in various organisms. While most …