Propofol (2, 6-diisopropylphenol) is administered intravenously for induction and
maintenance of anesthesia; however, cases of progressive myocardial failure (propofol …

Purpose Propofol is one of the most widely used fast-acting intravenously administered
anesthetics. However, although large inter-individual differences in dose requirements and …

Purpose The basis of high intersubject variability of propofol metabolism is unclear.
Therefore, we examined the influence of genetic polymorphisms of the key metabolizing …

Abstract Propofol (2, 6-diisopropylphenol) is one of the safest and most commonly used
anaesthetic agents for intravenous general anaesthesia. However, in clinical practice, a …

Interindividual variability in response to drugs used in anesthesia has long been considered
the rule, not the exception. It is important to mention that in anesthesiology, the variability in …

A variety of techniques have been developed to monitor the depth of anaesthesia. Propofol's
pharmacokinetics and response vary greatly, which might be explained by genetic …

Abstract Background and Objectives Propofol is the most commonly used hypnotic
worldwide, but its effective dose varies greatly between individuals. The present study …

Purpose This study was conducted to determine the effect of UGT1A9 98T> C, CYP2B6
516G> T and CYP2C9 430C> T genetic polymorphisms on the pharmacokinetics of propofol …

Objective The primary aim of this article is to test the hypothesis that nonparametric
pharmacometric modeling will accurately identify CYP2B6 genotype subgroups based on …

Background and objectiveThe objectives of this study were, firstly, to characterize the inter-
patient variability in the dose of propofol required to achieve a bispectral index< 70 and 'time …