Objective: Investigation of the effect of endothelin receptor A (ETaR)-targeting small
interfering RNA (siRNA) on rat vascular endothelial cellular hypoxia injury, as well as its …

Abstract Endothelin-1 (ET-1)-induced cell damage is commonly involved in
ischemia/hypoxia-associated diseases. PD155080 [sodium 2-benzo (1.3) dioxol-5-yl-3 …

Aims To investigate the protective effects of downregulating ETaR expression on renal
ischemia reperfusion injury (IRI). Main methods The renal IRI model was generated by …

Background As prolonged hyperoxia induces extensive lung tissue damage, we set out to
investigate the involvement of endothelin-1 (ET-1) receptors in these adverse changes …

Endothelin A receptor (ETaR) is a key molecule involved in a variety of biological events
such as vessel contraction and inflammatory response in ischemia-reperfusion (I/R) injury …

Endothelin-I (ET-1) is a vasoconstrictor peptide that may play an important role in the
pathophysiology of severe trauma. We examined ET-1 gene expression in vital organs (i, e …

Renal ischemia/reperfusion (I/R) is a common risk factor for renal failure. Expression of
endothelin‑1 (ET‑1) and its receptor ETA were also reported to be involved in the …

Our previous studies demonstrated that exposure to hypoxia increases pulmonary artery
pressure and plasma endothelin-1 (ET-1) levels and selectively enhances ET-1 gene …

Background High‐altitude pulmonary oedema (HAPE) is a form of noncardiogenic
pulmonary oedema. Studies have found that long noncoding RNA (lncRNA) plays an …

Abstract Objectives: Endothelin-1 (ET-1) is a potent vasoconstrictor that is expressed in
endothelial cells and in many other cells and tissues. Increased plasma levels of the peptide …