RNA interference (RNAi) for anti-angiogenic or pro-apoptotic factors in endothelial cells
(ECs) has great potential for the treatment of ischemic diseases by promoting angiogenesis …

Background Obstructive sleep apnea is a frequent medical condition consisting of repetitive
sleep-related episodes of upper air ways obstruction and can lead to hypertension. Ang Ⅱ …

Levels of the endothelium-derived vasoconstrictor endothelin (ET)-1 and the vasodilator
nitric oxide (NO) are markedly increased in endotoxic shock, although the …

Nitro-fatty acids are reactive signaling mediators that are formed when unsaturated fatty
acids react with nitric oxide or nitric oxide–derived species. Nitro-fatty acids can modify …

Abstract Endothelin-1 (ET-1) is essential for mammalian development and life, but it has also
been implicated in increased cardiovascular risk under pathophysiological conditions. The …

Background Coronary artery remodelling and vasospasm is a complication of acute
myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the …

Endothelin (ET)-1, an endothelium-derived vasoconstrictor and mitogen, acts as an
antiapoptotic factor against serum deprivation–induced apoptosis of endothelial cells and …

Coronary artery disease results in progressive vascular stenosis associated with chronic
myocardial ischemia. Vascular endothelial growth factor (VEGF) stimulates endothelial cell …

Intermittent hypoxia (IH), the key property of obstructive sleep apnea (OSA), is closely
associated with endothelial dysfunction. Endothelial‐cell‐specific molecule‐1 (ESM‐1 …

This study examines the influence of receptor expression level on signaling pathways
activated via endothelin type A receptor (ET AR) expressed in Chinese hamster ovary cells …