Dysregulation of angiogenesis can be caused by hypoxia, which may result in severe
diseases of the heart, including coronary artery disease. Hypoxia‑inducible factor 1 (HIF‑1) …

Aims: Our previous studies have shown that Nn-butyl haloperidol iodide (F2) can antagonize
myocardial ischemia/reperfusion (I/R) injury by down-regulating the early growth response …

Abstract Endothelin-1 (ET-1), a peptide product of endothelial cells, is mitogenic for
fibroblasts and smooth muscle cells. In this study we examined the effect of hypoxia on ET-1 …

RNA interference is applied to study gene function in different organisms and in various cell
types. Little is known about the effect of RNA interference on human endothelial progenitor …

To evaluate the impact of hypoxia on the angiogenic capability of endothelial cells (ECs),
and further investigate whether the cyclooxygenase‐2 (COX‐2)/prostaglandin E2 (PGE2) …

EPAS1 (endothelial PAS domain protein 1), as the major effect gene for the adaptation to
chronic hypoxia, is required for hypoxic pulmonary hypertension (HPH). Downregulated …

Endothelin-1 (ET-1) is known as a potent stimulator of cell proliferation and as a
vasoconstrictor. It is believed that ET-1 contributes to the development of arterial diseases …

Abstract Silent information regulator 1 (SIRT1), a class III histone deacetylase, retards aging
and plays roles in cellular oxidative stress injury (OSI). However, the biological context in …

Abstract Hypoxia-increased endothelin-1 (ET-1) expression contributes to vasoconstriction
and vessel wall thickening, often seen in the progression of pulmonary hypertension. We …

Background Vascular endothelial growth factor (VEGF) is a specific endothelial mitogen and
chemoattractant that has been shown to be useful for inducing therapeutic angiogenesis in …