A method has been devised for the isolation of a secretory granule fraction from isolated rat
islets of Langerhans. The islets were homogenized in buffered sucrose, and the …

A partially purified secretory granule fraction, isolated from rat islets of Langerhans by
differential centrifugation, was used for investigating the stability of the beta granules during …

The ultrastructure of the beta granules is distinctly different in the islets of the rat, dog, cat,
rabbit, guinea pig and chicken. The variations are so characteristic that each species can be …

Beta granules isolated from rat islets of Langerhans and subjected only to phosphotungstic
acid had, in negatively stained images, a 50-A periodicity. This periodicity was also …

A previous ultrastructural study of the mechanism ofglucagon secretion from the alpha cells
of rabbit islets of Langerhans has suggested that the agranules disintegrate, forming small …

A-cells of the islets of Langerhans from normal rabbits as well as rabbits treated with insulin,
cortisone, or tolbutamide or subjected to a semistarvation diet were studied by light and …

Secretory granule-enriched fractions prepared from isolated rat islets of Langerhans,
previously labeled in culture for 18 h with [3H] leucine, have been lysed and separated into …

Methods have been developed for the isolation on a semi-micro scale of a plasma
membrane-enriched fraction from rat islets of Langerhans. An important feature of these …

A simple method for the isolation of intact islets from the normal rat pancreas is described.
The method is based upon disruption of the acinar parenchyma by injecting Hanks solution …

A comparative study of the pancreatic islets of Langerhans was undertaken in which
correlative thick-thin sectioning techniques for light and electron microscopy were used. This …