Peripherally produced CRH acts as a local auto/paracrine proinflammatory agent. Urocortin
is a new member of the CRH family that acts through the family of CRH receptors. In this …

Urocortin is a newly identified member of the corticotropin-releasing factor (CRF)
neuropeptide family, and is known to be involved in the modulation of the inflammatory …

The hypothalmus‐pituitary‐adrenal (HPA) axis and the immune system communicate at
multiple levels: On the one hand, immune system‐derived substances, such as interleukin …

Objective To investigate the potential therapeutic action of the immunomodulatory
neuropeptide urocortin (UCN) in an experimental model of rheumatoid arthritis (RA) …

The presence of CRH and urocortin (Ucn), members of the CRH family of neuropeptides,
was examined in human gastric biopsies from normal controls and in patients with active …

Hypothalamic corticotropin-releasing hormone (CRH) is the principal regulator of the
hypothalamus-pituitary-adrenal axis in mammals. In addition, immunoreactive CRH is also …

Urocortin (Ucn), a new mammalian member of the CRF family, is a candidate endogenous
ligand for type 2 CRF receptors. In a survey of peripheral tissues from adult male rats, we …

Inflammation normally results in enhanced synthesis and secretion of hypothalamic
corticotropin-releasing hormone (CRH) which, in turn, exerts antiinflammatory effects by …

Peptides encoded by the Urocortin (Ucn) II gene, also known as stresscopin-related peptide,
were recently identified as new members of the corticotropin-releasing factor (CRF) family …

Objective Elevated levels of corticotropin‐releasing hormone (CRH) are produced locally in
inflamed human synovial tissue, and previous observations indicate a role for CRH in the …