Objective The important role of serotonin-1A (5-hydroxytryptamine-1A [5-HT 1A]) receptors
in cognition, behavior, and drug response is increasingly being recognized. Postmortem …

Serotonin (5-HT) and more specifically the 5-HT2A receptor is involved in cognitive and non-
cognitive behavior and plays an important role in Alzheimer's disease (AD). The objective …

Aims Positron emission tomography (PET) imaging using 5‐HT 1A receptor radioligands
shows a decreased expression of this serotonin receptor in the hippocampus of patients with …

OBJECTIVE: To determine whether there are abnormalities in the in vivo status of the
serotonin type 2A (5-HT2A) receptor in late-life depression and Alzheimer's disease, the …

Previous studies of patients with Alzheimer's disease (AD) have described reduced brain
serotonin 2A (5-HT2A) receptor density. It is unclear whether this abnormality sets in early in …

4-[F-18] fluoro-N-{2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl}-N-(2-pyridinyl) benzamide, a
selective serotonin 1A (5-HT1A) molecular imaging probe, was used in conjunction with …

We previously demonstrated a 20–30% reduction in cortical 5-HT2A receptor binding in
patients with mild cognitive impairment (MCI) as compared to healthy subjects. Here we …

In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed
early and prominent reductions in cerebral serotonin 2A (5-HT2A) receptors. To establish if …

Postmortem studies show reductions in brain serotonin 2A (5-HT2A) receptors in
Alzheimer's disease (AD). Converging evidence also suggests that serotonergic …

Decreased 5‐HT1A receptor binding has been associated with Alzheimer's disease (AD)
and interpreted as a consequence of neuron loss. The purpose of the present study was to …