Uncompleted epigenetic reprogramming is attributed to the low efficiency of producing
transgenic cloned animals. Histone modification associated with epigenetics can directly …

The purpose of this study was to investigate the effects of the histone deacetylase (HDAC)
inhibitor trichostatin A (TSA) on transgene expression and development of porcine …

The low success rate of somatic cell nuclear transfer (SCNT) is primarily due to incomplete
reprogramming of the transferred nuclei. As an inhibitor of histone deacetylase, trichostatin A …

Abnormal epigenetic reprogramming, such as histone acetylation, might cause low
efficiency of interspecies somatic cell nuclear transfer (iSCNT). This study was conducted to …

Reprogramming impairment of DNA methylation may be partly responsible for the low
efficiency in somatic cell nuclear transfer. In this study, bovine fibroblast cells were …

The application of cloning technology on a large scale is limited by very low offspring rate
primarily due to aberrant or incomplete epigenetic reprogramming. Trichostatin A (TSA), a …

Until now, the efficiency of animal cloning by somatic cell nuclear transfer (SCNT) has
remained low. Efforts to improve cloning efficiency have demonstrated a positive role of …

Epigenetic aberrancies likely preclude correct and complete nuclear reprogramming after
somatic cell nucleus transfer (SCNT) and may underlie the observed reduced viability of …

It has been reported that buffalo (Bubalus bubalis) embryos reconstructed by somatic cell
nucleus transfer (SCNT) can develop to the full term of gestation and result in newborn …

Trichostatin A (TSA), a histone deacetylase inhibitor, has been used to improve nuclear
reprogramming in somatic cell nuclear transfer embryos. However, the molecular …