Microneedle array: applications, recent advances, and clinical pertinence in transdermal drug delivery

J Halder, S Gupta, R Kumari, GD Gupta… - Journal of Pharmaceutical …, 2021 - Springer
Drug delivery through the skin by transdermal patches has a long history. Subsequent
growth of transdermal science proved prominent utility of transdermal systems meant for …

Hydrogel-forming microneedles with applications in oral diseases management

Y Li, D Bi, Z Hu, Y Yang, Y Liu, WK Leung - Materials, 2023 - mdpi.com
Controlled drug delivery in the oral cavity poses challenges such as bacterial contamination,
saliva dilution, and inactivation by salivary enzymes upon ingestion. Microneedles offer a …

Microneedles for transdermal drug delivery

MR Prausnitz - Advanced drug delivery reviews, 2004 - Elsevier
The success of transdermal drug delivery has been severely limited by the inability of most
drugs to enter the skin at therapeutically useful rates. Recently, the use of micron-scale …

Recent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing

M Wang, L Hu, C Xu - Lab on a Chip, 2017 - pubs.rsc.org
Microneedles are an efficient and minimally invasive approach to transdermal drug delivery
and extraction of skin interstitial fluid. Compared to solid microneedles made of silicon …

In vivo assessment of safety of microneedle arrays in human skin

SM Bal, J Caussin, S Pavel, JA Bouwstra - European Journal of …, 2008 - Elsevier
Microneedle arrays are promising devices for the delivery of drugs and vaccines into or the
skin. However, little is known about the safety of the microneedles. In this study we obtained …

Trends of microneedle technology in the scientific literature, patents, clinical trials and internet activity

RSJ Ingrole, E Azizoglu, M Dul, JC Birchall, HS Gill… - Biomaterials, 2021 - Elsevier
The powerful and intriguing idea that drives the emerging technology of microneedles—
shrinking the standard needle to a micron scale—has fostered an entire field of microneedle …

Microneedles: a valuable physical enhancer to increase transdermal drug delivery

JJ Escobar‐Chávez, D Bonilla‐Martínez… - The Journal of …, 2011 - Wiley Online Library
Transdermal drug delivery offers an attractive alternative to the conventional drug delivery
methods of oral administration and injection. However, the stratum corneum acts as a barrier …

Hydrogel‐forming microneedles: current advancements and future trends

JG Turner, LR White, P Estrela… - Macromolecular …, 2021 - Wiley Online Library
In this focused progress review, the recent developments and trends of hydrogel‐forming
microneedles (HFMs) and potential future directions are presented. Previously …

Two-photon polymerization of microneedles for transdermal drug delivery

SD Gittard, A Ovsianikov, BN Chichkov… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: Microneedles are small-scale devices that are finding use for
transdermal delivery of protein-based pharmacologic agents and nucleic acid-based …

Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population

S Duarah, M Sharma, J Wen - European journal of pharmaceutics and …, 2019 - Elsevier
Transdermal drug delivery offers several attractive advantages over the traditional oral and
parenteral routes. Particularly, in case of paediatric patients, it helps to overcome the issues …