Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells

G Ouyang, Z Wang, X Fang, J Liu, CJ Yang - Cellular and Molecular Life …, 2010 - Springer
The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that
allows polarized, well-differentiated epithelial cells to convert to unpolarized, motile …

Epithelial–mesenchymal plasticity: a central regulator of cancer progression

X Ye, RA Weinberg - Trends in cell biology, 2015 - cell.com
The epithelial–mesenchymal transition (EMT) program has emerged as a central driver of
tumor malignancy. Moreover, the recently uncovered link between passage through an EMT …

Epithelial–mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

T Chen, Y You, H Jiang, ZZ Wang - Journal of cellular …, 2017 - Wiley Online Library
The lineage transition between epithelium and mesenchyme is a process known as
epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their …

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

A Dongre, RA Weinberg - Nature reviews Molecular cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

[HTML][HTML] Communication between epithelial–mesenchymal plasticity and cancer stem cells: New insights into cancer progression

X Zheng, F Dai, L Feng, H Zou, L Feng, M Xu - Frontiers in Oncology, 2021 - frontiersin.org
The epithelial–mesenchymal transition (EMT) is closely associated with the acquisition of
aggressive traits by carcinoma cells and is considered responsible for metastasis, relapse …

Epithelial‐mesenchymal Transition and Cancer Stem Cells: At the Crossroads of Differentiation and Dedifferentiation

H Wang, JJ Unternaehrer - Developmental Dynamics, 2019 - Wiley Online Library
In this review, we explore the connections between epithelial‐mesenchymal transition (EMT)
and differentiation status. EMTs in development have been described as differentiation …

Epithelial–mesenchymal transition in development and cancer

DS Micalizzi, HL Ford - Future oncology, 2009 - Future Medicine
The epithelial–mesenchymal transition (EMT) is a critical developmental process from the
earliest events of embryogenesis to later morphogenesis and organ formation. EMT …

Concise review: stem cells and epithelial-mesenchymal transition in cancer: biological implications and therapeutic targets

R Sato, T Semba, H Saya, Y Arima - Stem cells, 2016 - academic.oup.com
Cancer stem cells (CSCs) constitute a small subpopulation of cancer cells with stem-like
properties that are able to self-renew, generate differentiated daughter cells, and give rise to …

[HTML][HTML] Epithelial-mesenchymal transition-activating transcription factors-multifunctional regulators in cancer

M Garg - World journal of stem cells, 2013 - ncbi.nlm.nih.gov
The process of epithelial to mesenchymal transition (EMT), first noted during
embryogenesis, has also been reported in tumor formation and leads to the development of …

[PDF][PDF] Epithelial-mesenchymal plasticity in cancer progression and metastasis

W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …