Phenotypic plasticity and epithelial‐mesenchymal transitions in cancer and normal stem cells?

C Scheel, RA Weinberg - International journal of cancer, 2011 - Wiley Online Library
Cancer stem cells (CSCs) are similar to normal stem cells in their ability to self‐renew and to
generate large populations of more differentiated descendants. In contrast to the hierarchical …

EMT, cell plasticity and metastasis

CL Chaffer, BP San Juan, E Lim… - Cancer and Metastasis …, 2016 - Springer
Carcinoma cells that are induced to suppress their epithelial features and upregulate
mesenchymal gene expression programs acquire traits that promote an invasive and …

Epithelial-to-mesenchymal transition: lessons from development, insights into cancer and the potential of EMT-subtype based therapeutic intervention

J Antony, JP Thiery, RYJ Huang - Physical biology, 2019 - iopscience.iop.org
Epithelial-to-mesenchymal transition (EMT) is a fundamental developmental process
wherein polarized epithelial cells lose their junctional architecture and apical-basal polarity …

The epithelial-mesenchymal transition and cancer stem cells: functional and mechanistic links

X Liu, D Fan - Current pharmaceutical design, 2015 - ingentaconnect.com
The epithelial-mesenchymal transition (EMT) is a highly conserved cellular process that
transforms epithelial cells into mesenchymal cells; EMT is involved in normal …

[HTML][HTML] EMT imparts cancer stemness and plasticity: new perspectives and therapeutic potential

S Roy, RR Sunkara, MY Parmar, S Shaikh… - Frontiers in Bioscience …, 2020 - imrpress.com
Epithelial-to-mesenchymal transition (EMT) is a fundamental cellular phenomenon that
plays an intrinsic role in development, tissue repair, and cancer progression. EMT is tightly …

Links between cancer stem cells and epithelial–mesenchymal transition

S Wang, J Jiang, X Liang, Y Tang - OncoTargets and therapy, 2015 - Taylor & Francis
The epithelial–mesenchymal transition (EMT) has been reported to be an important program
that is often activated during the process of cancer invasion and metastasis. Cancer stem …

Cancer stem cells and epithelial–mesenchymal transition: concepts and molecular links

C Scheel, RA Weinberg - Seminars in cancer biology, 2012 - Elsevier
The epithelial–mesenchymal transition (EMT) confers mesenchymal properties on epithelial
cells and has been closely associated with the acquisition of aggressive traits by carcinoma …

Epithelial-to-mesenchymal transition in tumor progression

E Prieto-García, CV Díaz-García, I García-Ruiz… - Medical Oncology, 2017 - Springer
The epithelial-to-mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal state with invasive capacities. However, the EMT …

Dynamic EMT: a multi‐tool for tumor progression

S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021 - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment

ET Roussos, Z Keckesova, JD Haley, DM Epstein… - 2010 - AACR
Epithelial-mesenchymal transition (EMT) is a developmental program implicated in cancer
progression and was the subject of the 2010 AACR meeting on the topic of EMT and Cancer …