Clinical data suggest that gender dimorphic profiles are emerging in terms of both drug
efficacy and adverse drug reactions (ADRs). With an increasing emphasis on individualised …

This review summarizes gender differences (GDs) in drug response. Although GDs have
been described both in pharmacodynamics and pharmacokinetics, their role in clinical …

Pharmacological response depends on multiple factors and one of them is sex–gender.
Data on the specific effects of sex–gender on pharmacokinetics, as well as the safety and …

Abstract Professor Henry Higgins in My Fair Lady said,'Why can'ta woman be more like a
man?'Perhaps unintended, such narration extends to the reality of current drug …

Background Women experience adverse drug reactions, ADRs, nearly twice as often as
men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood …

In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

The Food and Drug Administration (FDA) reviewed 300 new drug applications between
1995 and 2000. Of the 163 that included a sex analysis, 11 drugs showed a> 40% difference …

Female sex has been shown to be a risk factor for clinically relevant adverse drug reactions.
Is the increased risk due to sex differences in pharmacokinetics, in pharmacodynamics, or …

This is the very first book to deal with sex and gender differences in drug therapy-an
increasingly recognized medical need. It starts with an overview on S/G in clinical …

Gender-related differences in pharmacokinetics have frequently been considered as
potentially important determinants for the clinical effectiveness of drug therapy. The …