Anti-inflammatory properties of drugs used to control COVID-19 and their effects on the renin-angiotensin system and angiotensin-converting enzyme-2

H Gilzad-Kohan, F Jamali - Journal of Pharmacy & …, 2020 - journals.library.ualberta.ca
COVID-19 infection is associated with systemic inflammation, and sometimes
hyperinflammatory responses with cytokine storm. This plays a major role in COVID-19 …

Why severe COVID-19 patients are at greater risk of developing depression: a molecular perspective

AP Boucas, J Rheinheimer… - The …, 2022 - journals.sagepub.com
The prevailing evidence suggests that patients with severe COVID-19 seem to have an
overreaction of the immune system demonstrating exacerbated levels of inflammation …

[PDF][PDF] COVID-19: The role of angiotensin-2 receptor in transmission process

S Bittmann - J Regen Biol Med, 2020 - academia.edu
In early December 2019, a series of pneumonia cases of unknown origin occurred in
Wuhan, Hubei Province, China. Most of these patients reported that they had come into …

Broadening COVID-19 Interventions to Drug innovation: neprilysin pathway as a friend, foe, or promising molecular target?

DAB Rex, ST Arun Kumar, PK Modi… - OMICS: A Journal of …, 2021 - liebertpub.com
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is anticipated to transition to an …

Neuropilin is a new player in the pathogenesis of COVID-19

OA Gomazkov - Neurochemical Journal, 2022 - Springer
A family of glycoproteins called neuropilins is gaining attention as a new contributor to the
pathogenesis of COVID-19. The concept of penetration of SARS-CoV-2 into host cells is …

Immunomodulatory and clinical effects of receptor-interacting protein kinase 1 (RIPK1) inhibitor eclitasertib (SAR443122) in patients with severe COVID-19: a phase …

PF Clot, C Farenc, BT Suratt, T Krahnke, A Tardat… - Respiratory …, 2024 - Springer
Background Targeting receptor-interacting serine/threonine protein kinase 1 could mitigate
the devastating sequelae of the hyperinflammatory state observed in severe cases of COVID …

Not only ACE2—the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated …

I Kyrou, HS Randeva, DA Spandidos… - Signal transduction and …, 2021 - nature.com
Two recently published studies published in Science by Daly et al. 1 and Cantuti-Castelvetri
et al. 2 identified neuropilin-1 (NRP1) as an additional cellular mediator which may facilitate …

Bradykinin as a probable aspect in SARS-Cov-2 scenarios: is bradykinin sneaking out of our sight?

SM Ghahestani, J Mahmoudi, S Hajebrahimi… - Iranian Journal of …, 2020 - ijaai.tums.ac.ir
The new virus SARS-CoV-2 is savagely spreading out over the world. The biologic studies
show that the target receptor for the virus might be angiotensin-converting enzyme 2 (ACE2) …

Potential of angiotensin-(1-7) in COVID-19 treatment

P Luna, M Fernanda Pérez… - Current Protein and …, 2023 - ingentaconnect.com
The new coronavirus currently named SARS-CoV-2 was announced by the World Health
Organization as the virus causing the COVID-19 pandemic. The pathogenesis of SARS-CoV …

Impaired kallikrein-kinin system in COVID-19 patients' severity

E Alfaro, E Díaz-García, S García-Tovar… - Frontiers in …, 2022 - frontiersin.org
COVID-19 has emerged as a devastating disease in the last 2 years. Many authors
appointed to the importance of kallikrein-kinin system (KKS) in COVID-19 pathophysiology …