Objective Autoreactive B cells play a key role in tissue injury in systemic autoimmune
disease, and therefore a treatment resulting in B cell depletion could have benefit. This open …

The CD137—CD137 ligand (CD137L) costimulatory system is a critical immune checkpoint
with pathophysiological implications in autoimmunity. In this study, we investigated the role …

Systemic lupus erythematosus is a complex autoimmune disorder characterized by the
production of pathogenic anti-nuclear antibodies. Previous work from our laboratory has …

Mice with chronic graft‐versus‐host disease (GVHD), induced by injection of DBA/2
lymphocytes in (C57BL10* DBA/2) F1 hybrids, develop a syndrome resembling systemic …

Multiple mechanisms contribute to the pathogenesis of spontaneous SLE. However, despite
the presence of polyclonal T and B cell hyperactivity, autoimmunity in lupus is not global, it is …

NZB/WF 1 mice with established nephritis were treated with a single dose of
cyclophosphamide with or without a 2-wk course of murine CTLA4Ig, either alone or in …

Objective Treatment with anti‐CD154 antibody is known to ameliorate murine lupus
nephritis when given early in the disease. The aims of this study were to identify the …

B cells play critical roles in the pathogenesis of lupus. To examine the influence of B cells on
disease pathogenesis in a murine lupus model, New Zealand Black and New Zealand White …

Costimulatory blockade with CTLA4Ig and anti-CD40L along with a single dose of
cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/WF …

Objectives: Systemic lupus erythematosus (SLE) is a classical autoimmune disorder
characterised by the production of IgG autoantibodies against double-stranded DNA …