Context: Aging is associated with insulin resistance and unfavorable changes in body
composition including increased fat accumulation, particularly in visceral and ectopic …

OBJECTIVE Reductions in insulin sensitivity in conjunction with muscle mitochondrial
dysfunction have been reported to occur in many conditions including aging. The objective …

Background Skeletal muscle insulin resistance and reduced mitochondrial capacity have
both been reported to be affected by aging. The purpose of this study was to compare the …

The transition from young to adult age is associated with decreased insulin sensitivity. To
investigate whether changes in skeletal muscle mitochondrial function could be involved in …

Background: Insulin resistance, ie impaired insulin sensitivity, and type 2 diabetes are more
prevalent in elderly humans. Both conditions relate to lower aerobic performance and …

Mitochondria within skeletal muscle have been implicated in insulin resistance of obesity
and type 2 diabetes mellitus as well as impaired muscle function with normal aging …

The emerging concept that insulin stimulates mitochondrial protein synthesis and function
indicates potential novel molecular mechanisms of metabolic defects in type 2 diabetes …

Previous studies have implicated age-associated reductions in mitochondrial oxidative
phosphorylation activity in skeletal muscle as a predisposing factor for intramyocellular lipid …

Aging has been reported to be accompanied by reduced mitochondrial function and insulin
sensitivity. Whether these deleterious effects result from chronological age or lifestyle …

Background Mitochondrial function declines with age; however, the relationship between
adiposity and mitochondrial function among older adults is unclear. This study examined …