Intravenous injection of mesenchymal stem cell spheroids improves the pulmonary delivery and prolongs in vivo survival

Y Shimazawa, K Kusamori, M Tsujimura… - Biotechnology …, 2022 - Wiley Online Library
Background Because of the excellent therapeutic potential, mesenchymal stem cells (MSCs)
have been used as cell therapeutics for various diseases. However, the survival rate and …

The role of microvesicles derived from mesenchymal stem cells in lung diseases

J Chen, C Li, L Chen - BioMed Research International, 2015 - Wiley Online Library
Microvesicles (MVs) are membrane vesicles that are released by many types of cells and
have recently been considered important mediators of cell‐to‐cell communication. MVs …

Therapeutic potential of mesenchymal stem cells and their products in lung diseases—intravenous administration versus inhalation

E Fröhlich - Pharmaceutics, 2021 - mdpi.com
The number of publications studying the therapeutic use of stem cells has steadily increased
since 2000. Compared to other applications, there has been little interest in the evaluation of …

Collagen–Mesenchymal Stem Cell Microspheres Embedded in Hyaluronic Acid Solutions as Biphasic Stem Niche Delivery Systems for Pulmonary Differentiation

F Della Sala, G Longobardo… - ACS Applied Bio …, 2024 - ACS Publications
Cell therapy has the potential to become a feasible solution for several diseases, such as
those related to the lungs and airways, considering the more beneficial intratracheal …

Intrapleural delivery of mesenchymal stem cells: a novel potential treatment for pleural diseases

Z Qin, J Qu, J Xu, J Zhang, H Summah… - Acta Pharmacologica …, 2011 - nature.com
Aim: To develop a method to deliver mesenchymal stem cells (MSCs) into the pleural cavity
for the treatment of pleural diseases. Methods: MSCs were isolated from rat bone marrow of …

Biodistribution of mesenchymal stromal cells after administration in animal models and humans: a systematic review

M Sanchez-Diaz, MI Quiñones-Vico… - Journal of Clinical …, 2021 - mdpi.com
Mesenchymal Stromal Cells (MSCs) are of great interest in cellular therapy. Different routes
of administration of MSCs have been described both in pre-clinical and clinical reports …

Effects of mesenchymal stem cell coculture on human lung small airway epithelial cells

E Schmelzer, V Miceli, CM Chinnici… - BioMed research …, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) and their secreted extracellular vesicles have been used
effectively in different lung disease animal models and clinical trials. Their specific beneficial …

Cardiopulmonary and histological characterization of an acute rat lung injury model demonstrating safety of mesenchymal stromal cell infusion

RK Braun, JM Koch, TA Hacker, D Pegelow, J Kim… - Cytotherapy, 2016 - Elsevier
Background aims In the field of cellular therapy, potential cell entrapment in the lungs
following intravenous administration in a compromised or injured pulmonary system is an …

[HTML][HTML] Therapeutic use of stem cell transplantation for cell replacement or cytoprotective effect of microvesicle released from mesenchymal stem cell

M Choi, T Ban, T Rhim - Molecules and cells, 2014 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is the most common and severe type of idiopathic
interstitial pneumonias (IIP), and which is currently no method was developed to restore …

Intravenous administration of bone marrow mesenchymal stromal cells is safe for the lung in a chronic myocardial infarction model

W Wang, Q Jiang, H Zhang, P Jin, X Yuan… - Regenerative …, 2011 - Future Medicine
Aims: Intravenous administration of bone marrow mesenchymal stromal cells (MSCs) is an
attractive option for the treatment of myocardial infarction (MI). Previous studies revealed that …