Reflectance spectroscopy for diagnosis of epithelial precancer: model-based analysis of fiber-optic probe designs to resolve spectral information from epithelium and …

D Arifler, RA Schwarz, SK Chang… - Applied optics, 2005 - opg.optica.org
Reflectance spectroscopy is a promising technology for detection of epithelial precancer.
Fiber-optic probes that selectively collect scattered light from both the epithelium and the …

Enhancing the sensitivity to scattering coefficient of the epithelium in a two-layered tissue model by oblique optical fibers: Monte Carlo study

KB Sung, HH Chen - Journal of biomedical optics, 2012 - spiedigitallibrary.org
Diffuse reflectance spectroscopy has been applied to detect tissue absorption and scattering
properties associated with dysplasia, which is a potential precursor of epithelial cancers …

Depth-sensitive reflectance measurements using obliquely oriented fiber probes

AMJ Wang, JE Bender, J Pfefer… - … of biomedical optics, 2005 - spiedigitallibrary.org
Computer simulation is used to facilitate the design of fiber-probe geometries that enable
enhanced detection of optical signals arising from specific tissue depths. Obtaining …

Validity of the semi-infinite tumor model in diffuse reflectance spectroscopy for epithelial cancer diagnosis: a Monte Carlo study

C Zhu, Q Liu - Optics Express, 2011 - opg.optica.org
The accurate understanding of optical properties of human tissues plays an important role in
the optical diagnosis of early epithelial cancer. Many inverse models used to determine the …

Targeting spectral signatures of progressively dysplastic stratified epithelia using angularly variable fiber geometry in reflectance Monte Carlo simulations

A Wang, V Nammalavar… - Journal of biomedical …, 2007 - spiedigitallibrary.org
A key component of accurate spectroscopic-based cancer diagnostics is the ability to
differentiate spectral variations resulting from epithelial tissue dysplasia. Such measurement …

A low-cost, portable, and quantitative spectral imaging system for application to biological tissues

HL Fu, B Yu, JY Lo, GM Palmer, TF Kuech… - Optics …, 2010 - opg.optica.org
The ability of diffuse reflectance spectroscopy to extract quantitative biological composition
of tissues has been used to discern tissue types in both pre-clinical and clinical cancer …

Monte Carlo analysis of single fiber reflectance spectroscopy: photon path length and sampling depth

SC Kanick, DJ Robinson, H Sterenborg… - Physics in Medicine & …, 2009 - iopscience.iop.org
Single fiber reflectance spectroscopy is a method to noninvasively quantitate tissue
absorption and scattering properties. This study utilizes a Monte Carlo (MC) model to …

Influence of fiber optic probe geometry on the applicability of inverse models of tissue reflectance spectroscopy: computational models and experimental …

J Sun, K Fu, A Wang, AWH Lin, U Utzinger… - Applied optics, 2006 - opg.optica.org
Accurate recovery of tissue optical properties from in vivo spectral measurements is crucial
for improving the clinical utility of optical spectroscopic techniques. The performance of …

Comparison of a physical model and principal component analysis for the diagnosis of epithelial neoplasias in vivo using diffuse reflectance spectroscopy

MC Skala, GM Palmer, KM Vrotsos… - Optics express, 2007 - opg.optica.org
We explored the use of diffuse reflectance spectroscopy in the ultraviolet-visible (UV-VIS)
spectrum for the diagnosis of epithelial pre-cancers and cancers in vivo. A physical model …

Accurate extraction of optical properties and top layer thickness of two-layered mucosal tissue phantoms from spatially resolved reflectance spectra

KB Sung, KW Shih, FW Hsu, HP Hsieh… - … of biomedical optics, 2014 - spiedigitallibrary.org
We are reporting on an experimental investigation of a movable diffuse reflectance
spectroscopy system to extract diagnostically relevant optical properties of two-layered …