Cytomegalovirus drug resistance and clinical implications

SW Chou - Transplant Infectious Disease, 2001 - Wiley Online Library
Antiviral agents are commonly used for cytomegalovirus (CMV) prophylaxis or therapy after
solid organ transplantation. Until recently, the detection of drug‐resistant CMV in this setting …

Cytomegalovirus resistance in solid organ transplant recipients treated with intravenous ganciclovir or oral valganciclovir

G Boivin, N Goyette, H Rollag, AG Jardine… - Antiviral …, 2009 - journals.sagepub.com
Background The rate of cytomegalovirus (CMV) mutations conferring ganciclovir resistance
was assessed in a trial comparing intravenous ganciclovir and oral valganciclovir for …

Absence of cytomegalovirus-resistance mutations after valganciclovir prophylaxis, in a prospective multicenter study of solid-organ transplant recipients

G Boivin, N Goyette, C Gilbert, N Roberts… - The Journal of …, 2004 - academic.oup.com
We investigated the emergence of cytomegalovirus (CMV) ganciclovir-resistance mutations
in 301 high-risk solid-organ transplant (SOT) recipients after oral prophylaxis, for 100 days …

Clinical aspects of cytomegalovirus antiviral resistance in solid organ transplant recipients

AK Le Page, MM Jager, JM Iwasenko… - Clinical infectious …, 2013 - academic.oup.com
Despite advances in the prophylaxis and acute treatment of cytomegalovirus (CMV), it
remains an important pathogen affecting the short-and long-term clinical outcome of solid …

The emergence of cytomegalovirus resistance to ganciclovir therapy in kidney transplant recipients

E Nogueira, KS Ozaki, H Tomiyama… - International …, 2006 - Elsevier
Transplant recipients that have not been previously exposed to the cytomegalovirus (CMV)
are highly susceptible to viral diseases while under immunosuppression therapy. CMV …

Drug-resistant cytomegalovirus in transplant recipients: a French cohort study

S Hantz, F Garnier-Geoffroy… - Journal of …, 2010 - academic.oup.com
Objectives Cytomegalovirus (CMV) drug resistance is a therapeutic challenge in the
transplant setting. No longitudinal cohort studies of CMV resistance in a real-life setting have …

Antiviral resistance in cytomegalovirus: an emerging problem in organ transplant recipients.

AP Limaye - Seminars in respiratory infections, 2002 - europepmc.org
In the era of more aggressive immunosuppressive regimens and antiviral prophylaxis,
ganciclovir-resistant cytomegalovirus (CMV) has been recognized as an important clinical …

Prevalence of cytomegalovirus antiviral drug resistance in transplant recipients

SB Kleiboeker - Antiviral Research, 2023 - Elsevier
Cytomegalovirus (CMV) is a significant human pathogen, especially for
immunocompromised patients, often treated with one or more antiviral drugs. Although the …

Emergence of drug‐resistant cytomegalovirus in the era of valganciclovir prophylaxis: therapeutic implications and outcomes

AJ Eid, SK Arthurs, PJ Deziel, MP Wilhelm… - Clinical …, 2008 - Wiley Online Library
Background: Valganciclovir prophylaxis is reportedly associated with a low incidence of
ganciclovir‐resistant cytomegalovirus (CMV). We assessed the incidence, clinical features …

Diversity of antiviral‐resistant human cytomegalovirus in heart and lung transplant recipients

JM Iwasenko, GM Scott, Z Naing… - Transplant Infectious …, 2011 - Wiley Online Library
JM Iwasenko, GM Scott, Z. Naing, AR Glanville, WD Rawlinson. Diversity of antiviral‐
resistant human cytomegalovirus in heart and lung transplant recipients. Transpl Infect Dis …