Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning

P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

S Lee, SM Jilani, GV Nikolova, D Carpizo… - The Journal of cell …, 2005 - rupress.org
Vascular endothelial growth factor (VEGF) is a critical mediator of blood vessel formation
during development and in pathological conditions. In this study, we demonstrate that VEGF …

Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action

N Ferrara - Molecular biology of the cell, 2010 - Am Soc Cell Biol
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and
pathological angiogenesis. One feature of VEGF is the existence of multiple isoforms arising …

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

TT Chen, A Luque, S Lee, SM Anderson… - Journal of cell …, 2010 - rupress.org
VEGF can be secreted in multiple isoforms with variable affinity for extracellular proteins and
different abilities to induce vascular morphogenesis, but the molecular mechanisms behind …

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

F Zhang, Z Tang, X Hou… - Proceedings of the …, 2009 - National Acad Sciences
VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an
important target in antiangiogenic therapy. Instead, it has received little attention from the …

Mechanisms and regulation of endothelial VEGF receptor signalling

M Simons, E Gordon, L Claesson-Welsh - Nature reviews Molecular …, 2016 - nature.com
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

Vascular endothelial growth factor biology for regenerative angiogenesis

A Uccelli, T Wolff, P Valente, N Di Maggio… - Swiss medical …, 2019 - smw.ch
Despite major advances in medical, catheter-based or surgical treatment, cardiovascular
diseases such as peripheral artery disease and coronary artery disease still cause …

Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis

P Vempati, AS Popel, F Mac Gabhann - BMC systems biology, 2011 - Springer
Background The spatial distribution of vascular endothelial growth factor A (VEGF) is an
important mediator of vascular patterning. Previous experimental studies in the mouse …

Growing and shaping the vascular tree: multiple roles for VEGF

C Ruhrberg - Bioessays, 2003 - Wiley Online Library
Abstract Vascular Endothelial Growth Factor (VEGF) is the most potent and ubiquitous
vascular growth factor known to date. Yet, prior to its description as a secreted mitogen for …

[HTML][HTML] Autocrine VEGF signaling is required for vascular homeostasis

S Lee, TT Chen, CL Barber, MC Jordan, J Murdock… - Cell, 2007 - cell.com
Vascular endothelial growth factor (VEGF) is essential for developmental and pathological
angiogenesis. Here we show that in the absence of any pathological insult, autocrine VEGF …