Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning
P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …
neovascularization in numerous tissues under physiological and pathological conditions …
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
S Lee, SM Jilani, GV Nikolova, D Carpizo… - The Journal of cell …, 2005 - rupress.org
Vascular endothelial growth factor (VEGF) is a critical mediator of blood vessel formation
during development and in pathological conditions. In this study, we demonstrate that VEGF …
during development and in pathological conditions. In this study, we demonstrate that VEGF …
Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action
N Ferrara - Molecular biology of the cell, 2010 - Am Soc Cell Biol
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and
pathological angiogenesis. One feature of VEGF is the existence of multiple isoforms arising …
pathological angiogenesis. One feature of VEGF is the existence of multiple isoforms arising …
Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells
TT Chen, A Luque, S Lee, SM Anderson… - Journal of cell …, 2010 - rupress.org
VEGF can be secreted in multiple isoforms with variable affinity for extracellular proteins and
different abilities to induce vascular morphogenesis, but the molecular mechanisms behind …
different abilities to induce vascular morphogenesis, but the molecular mechanisms behind …
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
F Zhang, Z Tang, X Hou… - Proceedings of the …, 2009 - National Acad Sciences
VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an
important target in antiangiogenic therapy. Instead, it has received little attention from the …
important target in antiangiogenic therapy. Instead, it has received little attention from the …
Mechanisms and regulation of endothelial VEGF receptor signalling
M Simons, E Gordon, L Claesson-Welsh - Nature reviews Molecular …, 2016 - nature.com
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …
required to balance the formation of new blood vessels with the maintenance and …
Vascular endothelial growth factor biology for regenerative angiogenesis
A Uccelli, T Wolff, P Valente, N Di Maggio… - Swiss medical …, 2019 - smw.ch
Despite major advances in medical, catheter-based or surgical treatment, cardiovascular
diseases such as peripheral artery disease and coronary artery disease still cause …
diseases such as peripheral artery disease and coronary artery disease still cause …
Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
P Vempati, AS Popel, F Mac Gabhann - BMC systems biology, 2011 - Springer
Background The spatial distribution of vascular endothelial growth factor A (VEGF) is an
important mediator of vascular patterning. Previous experimental studies in the mouse …
important mediator of vascular patterning. Previous experimental studies in the mouse …
Growing and shaping the vascular tree: multiple roles for VEGF
C Ruhrberg - Bioessays, 2003 - Wiley Online Library
Abstract Vascular Endothelial Growth Factor (VEGF) is the most potent and ubiquitous
vascular growth factor known to date. Yet, prior to its description as a secreted mitogen for …
vascular growth factor known to date. Yet, prior to its description as a secreted mitogen for …
[HTML][HTML] Autocrine VEGF signaling is required for vascular homeostasis
Vascular endothelial growth factor (VEGF) is essential for developmental and pathological
angiogenesis. Here we show that in the absence of any pathological insult, autocrine VEGF …
angiogenesis. Here we show that in the absence of any pathological insult, autocrine VEGF …