Endocytosis plays a crucial role in receptor signalling. VEGFR2 (also known as KDR) and its
ligand VEGFA are fundamental in neovascularisation. However, our understanding of the …

Background Blood vessels comprise endothelial cells, mural cells (pericytes/vascular
smooth muscle cells) and basement membrane. During angiogenesis, mural cells are …

Tumors, wounds, and chronic inflammatory disorders generate a new vascular supply by a
process known as pathological angiogenesis. Whereas formation of the normal blood …

Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system.
VEGFR1 is required for the recruitment of haematopoietic precursors and migration of …

The vascular endothelial growth factor (VEGF)/VEGF receptor system plays a central
regulatory role in physiological and pathological angiogenesis. During embryogenesis, the …

Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

The past 5 years have witnessed a significant expansion in our understanding of vascular
endothelial growth factor (VEGF) signaling. In particular, the process of canonical activation …

Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety
of cells to regulate diverse biological responses. The VEGF-A family member promotes …

Vascular endothelial growth factor A (VEGF‐A) belongs to a family of heparin binding growth
factors that include VEGF‐B, VEGF‐C, VEGF‐D, and placental‐like growth factor (PLGF) …

Angiogenesis, the growth of new blood vessels from pre-existing vasculature, is a key
process in several pathological conditions, including tumour growth and age-related …